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  • 1995-1999  (4)
  • 1975-1979
  • 1997  (4)
  • 1928
  • Classification Problems  (1)
  • O-methylcellulose  (1)
  • adaptive dynamics  (1)
  • bioavailability  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of substituent distribution on water solubility of O-methylcellulose (1997)
    Springer
    Cellulose 4 (1997), S. 321-327 
    Details
    ISSN: 1572-882X
    Schlagwort(e): O-methylcellulose ; water solubility ; substituents distribution ; regioselective substitution ; hydrogen bonding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Abstract The effect of substituent distribution on the water solubility of O-methylcellulose (MC) was re-examined to elucidate the lower limit of the degree of substitution (DS) in water-soluble MC. To this end, a series of 2,3-MCs which are regioselectively substituted at the C-2 and C-3 hydroxyl groups were prepared by homogeneous methylation. It was found that the lower limit for the DS value of water-soluble 2,3-MC was almost the same as that for MCs having even distributions of substituents along the cellulose chain as well as in the anhydroglucose units.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1018404426960
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and bioavailability of oral and intramuscular artemether (1997)
    Springer
    European journal of clinical pharmacology 52 (1997), S. 307-310 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Key words Artemether ; Thai males; malaria ; dihydroartemisinin ; pharmacokinetics ; bioavailability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Abstract Objective: The pharmacokinetics and bioavailability of artemether and dihydroartemisinin were investigated in eight Thai males following the administration of single oral and intramuscular doses of artemether (300 mg) in a randomized two-way cross-over study. Results: Both oral and intramuscular artemether were well-tolerated. In most cases, artemether and dihydroartemisinin were detected in plasma after 30 min and declined to levels below the limit of detection within 18–24 h. Compared with intramuscular administration, oral administration of artemether resulted in a relatively rapid but incomplete absorption [Cmax: 474 vs 540 ng · ml−1; t max: 2.0 vs 3.9 h; AUC: 2.17 vs 5.20 μg · h · ml−1]. Geographic means of lag-time and absorption half-life (t 1/2a) of oral vs intramuscular artemether were 0.28 and 1.1 h vs 0.30 and 2 h, respectively. t 1/2z was significantly shortened after the oral dose [2.8 vs 6.9 h]. Mean oral bioavailability relative to intramuscular administration was 43.2%. The ratio of the AUCs of artemether to dihydroartemisinin was significantly lower after the oral than after the intramuscular dose (geometric mean: 0.29 vs 0.60).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s002280050295
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  • 3
    Digitale Medien
    Digitale Medien
    Evolutionarily singular strategies and the adaptive growth and branching of the evolutionary tree (1997)
    Springer
    Evolutionary ecology 12 (1997), S. 35-57 
    Details
    ISSN: 1573-8477
    Schlagwort(e): adaptive dynamics ; evolutionarily singular strategy ; evolutionary branching ; evolutionary modelling
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract We present a general framework for modelling adaptive trait dynamics in which we integrate various concepts and techniques from modern ESS-theory. The concept of evolutionarily singular strategies is introduced as a generalization of the ESS-concept. We give a full classification of the singular strategies in terms of ESS-stability, convergence stability, the ability of the singular strategy to invade other populations if initially rare itself, and the possibility of protected dimorphisms occurring within the singular strategy's neighbourhood. Of particular interest is a type of singular strategy that is an evolutionary attractor from a great distance, but once in its neighbourhood a population becomes dimorphic and undergoes disruptive selection leading to evolutionary branching. Modelling the adaptive growth and branching of the evolutionary tree can thus be considered as a major application of the framework. A haploid version of Levene's ‘soft selection’ model is developed as a specific example to demonstrate evolutionary dynamics and branching in monomorphic and polymorphic populations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1006554906681
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  • 4
    Digitale Medien
    Digitale Medien
    Experiments of Fast Learning with High Order Boltzmann Machines (1997)
    Springer
    Applied intelligence 7 (1997), S. 287-303 
    Details
    ISSN: 1573-7497
    Schlagwort(e): Neural Networks ; Boltzmann Machines ; High Order networks ; Classification Problems
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Informatik
    Notizen: Abstract This work reports the results obtained with the application of High Order Boltzmann Machines without hidden units to construct classifiers for some problems that represent different learning paradigms. The Boltzmann Machine weight updating algorithm remains the same even when some of the units can take values in a discrete set or in a continuous interval. The absence of hidden units and the restriction to classification problems allows for the estimation of the connection statistics, without the computational cost involved in the application of simulated annealing. In this setting, the learning process can be sped up several orders of magnitude with no appreciable loss of quality of the results obtained.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1023/A:1008257203142
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