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Über einige β-substituierte Fettsäureamide mit lokalanästhetischer Wirkung (1955)

Wilder Smith, A. E. ; Hofstetter, Emil

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 38 (1955), S. 1085-1095

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: The preparation and properties of further fatty acid anilides showing anaesthetic action are described and the relationship between chemical constitution and physiological effect is discussed. Two very active compounds having relatively low toxicities have been discovered, namely:-β-piperidino-n-butyric-acid-2,4-dichloranilide (XIV) and β-(2-methylpiperidino)-n-butyric-acid-anilide (V). A number of similar anilides show high activities, but other undesirable properties such as tissue irritation render them less useful.

Additional Material: 3 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/hlca.19550380502

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