ISSN:
1432-2072
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Two piperidyl benzilates with known hallucinogenic properties were compared with two devoid of this action in ability to produce EEG synchrony, blockade to external stimuli, and blockade to EEG activation induced by physostigmine in rabbits and cats. The mg/kg dose necessary to produce EEG synchrony and inhibition of EEG activation of exteroceptive stimuli was lowest with JB 329 followed, in order of ascent, by JB 318, JB 305 and JB 340. Moreover, JB 329 was more efficacious in blocking the EEG effects of physostigmine (0.1 mg/kg to 0.5 mg/kg) than was JB 318 whereas the latter two compounds were devoid of this action. This study shows that, in contrast to reported peripheral effects, an excellent correlation exists between a central atropinelike effect of these drugs and reported psychotogenicity in humans. In addition to the fact that only the psychotogenic compounds exerted central atropine-like effects, they induced EEG synchrony in low doses which far outlasted even large doses of the non-psychotogenic substances. This latter finding, coupled with the much greater potency of the psychotomimetic agents, may also explain why JB 305 and JB 340 fail to induce hallucinogenic actions in humans since elimination may be rapid enough to prevent central actions by the oral route. Nevertheless, the fact that all of the piperidyl benzilates blocked the EEG effects of amphetamine, whereas only the psychotogenic group blocked EEG activation of physostigmine, supports the suggestion of others that these compounds may induce hallucinogenic phenomena by means of central anticholinergic mechanisms.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00403351
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