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  • 1960-1964  (3)
  • 1910-1914
  • 1963  (3)
Material
Years
  • 1960-1964  (3)
  • 1910-1914
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 85 (1963), S. 2686-2686 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 10 (1963), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS. The responses of a strain of Amoeba proteus to conditions which could give rise to induced increases in resistance to streptomycin have been investigated. An indirect selection method, based on survival time in high concentrations of streptomycin, was devised. All attempts to obtain substrains with enhanced sensitivity or enhanced resistance by indirect methods were unsuccessful. It was therefore concluded that increases in resistance observed as a result of other treatments were likely to be the result of adaptation of a majority of individuals, rather than selection of pre-existing resistant variants. Direct treatment with regularly increased concentrations of streptomycin led to a 10-fold increase in resistance of large cultures. Nuclear transfers were made by the de Fonbrune technique to produce resistant nucleus/normal cytoplasm, and normal cytoplasm/resistant nucleus combinations. Examination of the descendants of these ‘crosses’ showed that the resistance was nuclear dependent and not influenced by the cytoplasm. The resistance proved transitory, disappearing slowly during continued culture without further contact with streptomycin.These results are discussed with reference to possible mechanisms responsible for the increase in streptomycin resistance and its mode of origin.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 200 (1963), S. 1238-1239 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Because of the apparent closeness of the two loci, the observations of Werret et al. could also have been explained by assuming a small deletion rather than a point mutation. It was also possible that they were dealing with a different mutation from that studied by Hutt, which is known to have ...
    Type of Medium: Electronic Resource
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