Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
13 (1966), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Brain ganglioside pattern was studied in one case of Tay-Sachs’disease, two cases of Late Infantile Amaurotic Idiocy (L.I.A.I.) two cases of Juvenile Amaurotic Idiocy (J.A.I.), three cases of Gargoylism together with three normal adults and one 7-year-old normal child. Our findings in Tay-Sachs’disease conformed with those reported by previous authors. In J.A.I. and L.I.A.I. the percentage distribution of N-acetylneuraminic acid in individual gangliosides has been found to be similar to the normal. No evidence of storage of any single ganglioside has been found in L.I.A.I. All cases of gargoylism showed a clear-cut increase of the two fastest monosialogangliosides.Literature concerning Amaurotic Idiocy and Gargoylism is reviewed and briefly discussed in connection with the present findings.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1966.tb04284.x
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