ISSN:
0002-9106
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
Mice of the highly inbred C strain were used. Of these 146 were fed a completely adequate diet. These were 10-66 weeks old when killed. Beginning at 3-4 months of age 45 mice were fed a diet high in fat (40% lard), low in protein (8% casein) and deficient in lipotropic substances for 4-66 weeks.Livers were not fatty in mice fed the adequate diet. Hepatic fibrosis developing within 24 weeks of age, and increasing with age, was observed in more than 60% of these control mice. Fibrosis was usually subcapsular, but in some instances was perivenous or intralobular. Reticular fibers were the chief component.In those fed the atypical diet the livers were fatty in all mice killed during the 4-66 weeks of the study. At approximately 20 weeks liposis declined from the large amounts present earlier (4-18 weeks). Until 52 weeks most of the lipid was located in fatty cysts. Subsequently the livers became excessively fatty. Parenchymal necrosis was limited to three mice. Parenchymal hyperplasia was lacking.In the dietary group of mice there were three patterns of hepatic fibrosis. Subcapsular fibrosis developed within a month and was the most common type. Another type consisted of fibrous septa extending chiefly from central veins. Linkage of septa produced pseudolobulation or pseudoencapsulation of areas of parenchyma. The least common type was an intralobular fibrosis which was unrelated to the capsule or to veins. All three types consisted initially of reticular fibers. Collagen was present in subcapsular and perivenous fibrosis within 16 weeks and in the intralobular type by 52 weeks.
Additional Material:
3 Tab.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/aja.1001180206
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