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  • 1975-1979  (3)
  • 1965-1969  (3)
  • 1978  (3)
  • 1967  (3)
Material
Years
  • 1975-1979  (3)
  • 1965-1969  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of chemical documentation 7 (1967), S. 9-14 
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 30 (1978), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— The effects of altered osmolarity on respiration and fine structure were compared in isolated rat cerebral versus liver mitochondria.Polarographic study of cerebral mitochondria in hypo-osmolar media showed inhibition of State 3 (ADP-dependent) respiration which was not reversed by dinitrophenol. In hyperosmolar media, State 3 respiration was transiently inhibited and State 4 (ADP-independent) respiration increased with the NAD-linked substrate pair, glutamate and malate. With succinate as substrate, respiration was not affected by moderate hyperosmolarity. In the most hyperosmolar medium, State 3 respiration was inhibited with both substrates.In contrast to the results with cerebral mitochondria, State 4 respiration was increased in hypo-osmolar media and State 3 respiration was persistently inhibited in hyperosmolar media in liver mitochondria with both substrates.In both cerebral and liver mitochondria, cytochrome c oxidase (EC 1.9.3.1.) activity was mildly inhibited in hypo-osmolar media and increased in hyperosmolar media.Electron microscopy showed that liver mitochondria were swollen in hypo-osmolar media and condensed in hyperosmolar media. Cerebral mitochondria showed mild rarefaction in hypo-osmolar media and, in hyperosmolar media, more than half the mitochondria showed either no or minimal changes in fine structure.Our results suggest that there are differences in metabolic control and structure between mitochondria from different cell types, which may be important in the cellular metabolic response to pathologic changes in water or osmolarity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
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    Unknown
    Baltimore : Periodicals Archive Online (PAO)
    Human Biology. 39:3 (1967:Sept.) 284 
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 229 (1967), S. 7-19 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Haut von Kindern verschiedenen Alters wurde chemisch untersucht. Es wurde der Gehalt an Wasser, fettfreier Trockensubstanz, Gesamtstickstoff, Oxyprolin, Hexosamin, Asche, Calcium, Magnesium, Phosphorsäure, Eisen und Kupfer bestimmt. Es zeigte sich, daß sich der Gehalt an einigen dieser Komponenten mit dem Heranwachsen der Kinder auf charakteristische Weise ändert. Die Ergebnisse dieser Untersuchungen werden mit von anderen Autoren veröffentlichten Resultaten verglichen.
    Notes: Summary Samples of skin from children of different age were analysed by chemical methods. The content of water, fatfree dry residue, total nitrogen, hydroxyproline, hexosamine, total minerals, calcium, magnesium, phosphate, iron and copper were determined. It was found that the degree of hydratisation is highest in the skin of babies; it diminishes quickly during the first year of life and much more slowly till the age of about five years. Nitrogen content increases slowly with age and in the skin of young children a quickly increasing percentage of the total nitrogen is collagen nitrogen. Mineral content, particularly phosphorus and magnesium content, are much higher in the skin of babies than in that of older children. Results of our analyses differ in several respects from those of other authors. They seem to indicate that the chemical composition of children's skin undergoes changes which to the greatest part take place during the first year, but continue for several years.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 96 (1978), S. 23-29 
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Administration of radioactively labeled galactose to cultured mammalian cells brings about an accumulation of metabolic products the pattern of which seems to be governed by a variety of vectors in the intracellular milieu. By manipulation of culture conditions some of these vectors appear to be a function of glycolysis. In the non-glycolytic culture, label from a galactose probe appears as Galactose-1-phosphate (Gal-1-P) and UDPglucuronic acid (UDPGlcUA). Conversely, glycolytic culture conditions seem not to permit the formation to UDPGlcUA since the only labeled accumulation product formed was UDPHex. A suggestion is made that the difference in metabolic activity of glucose-fed and glucose-starved cultures may be related to the effect of NADH on the in situ activity of UDPG dehydrogenase (UDPglucose:NAD oxidoreductase, E.C. 1.1.1.22) (abbreviation, UDPG-DH). This prompted an investigation of the effects of NAD and NADH on the activity of partially purified UDPG-DH. The results of these experiments strongly suggest that the activity of UDPG-DH (in situ) is negatively controlled by increased levels of NADH; the latter condition is known to exist in glycolytically active cells (Schwartz and Johnson, 1976). Added to this is a second control mechanism which is characterized by a transient inhibition of uridylyltransferase (UDP glucose:α-D-galactose-1-phosphate uridylyltransferase, E.C. 2.7.7.12). Since it is known that there is little, if any, effect on galactokinase (ATP:D-galactose-1-phosphotransferase, E.C. 2.7.1.6) activity as a result of sugar starvation (Christopher et al., 1976), the low in vivo activity of uridylyltransferase contributes not only to the increased accumulation of Gal-1-P but also to a drastic decrease of labeled UDPhexoses, although the pre-existing pool of UDPhexose was found to decrease only moderately under the condition of glucose starvation (30% still persisted). The benefit of this type of control is not clear.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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