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  • 1995-1999  (2)
  • 1985-1989
  • 1965-1969
  • 1960-1964
  • 1998  (2)
  • 1967
  • Acute myeloid leukemia  (1)
  • containerless  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effects of thrombopoietin on megakaryocyte colony formation from leukemic cells at diagnosis and from marrow cells after induction chemotherapy for acute leukemias (1998)
    Springer
    Annals of hematology 77 (1998), S. 33-39 
    Details
    ISSN: 1432-0584
    Keywords: Keywords Thrombopoietin ; Megakaryocyte ; colony ; CFU-MK ; Acute myeloid leukemia ; Acute lymphoblastic leukemia ; Induction chemotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  We have studied the effects of recombinant human thrombopoietin (TPO, mpl ligand) on the megakaryocyte colony formation from control human bone marrow cells, human leukemia cells at diagnosis, and human bone marrow cells after induction chemotherapy for acute leukemias. In the control human bone marrow cells from four adults and nine children who had localized malignancy and histologically normal-looking marrow, TPO alone effectively stimulated megakaryocyte colony formation, and interleukin-3 (IL-3) synergized this. In 17 patients (13 adults and four children) with acute myeloid leukemia (AML) at diagnosis, TPO stimulated leukemic colony formation in only one patient with FAB M7 subtype. In 11 children with acute lymphoblastic leukemia (ALL) at diagnosis, TPO did not enhance leukemic colony formation. After 17 courses of induction chemotherapy, nine for AML and eight for ALL, TPO stimulated megakaryocyte colony formation to a level of 51% of that in the control human bone marrow cells. This may suggest that the administration of TPO to patients with M7 subtype warrants caution, whereas it is probably safe to give TPO at any time to patients with ALL. The administration of TPO to patients with acute leukemias after induction chemotherapy could stimulate megakaryocytopoiesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002770050408
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of Sample Size on Surface-Tension Measurements of Nickel in Reduced-Gravity Parabolic Flights (1998)
    Springer
    International journal of thermophysics 19 (1998), S. 817-826 
    Details
    ISSN: 1572-9567
    Keywords: surface tension ; oscillating drop ; containerless ; electromagnetic levitation ; nickel ; molten metals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Surface tensions of molten metals have been reported in the literature by application of many “standard” techniques: sessile-drop, maximum bubble pressure, pendant-drop, and capillary-rise methods. Great experimental care must be exercised to ensure the absence of contamination, and containerless techniques based upon the classical theory of oscillations of a liquid drop are being developed for high-precision measurements on reactive alloys. Droplet positioning and heating can be efficiently accomplished by electromagnetic levitation, although additional modes of oscillation can be excited and the fundamental oscillation mode can be shifted to higher frequencies due to asymmetries in droplet shape when experiments are performed in earth-based laboratories. These additional factors associated with 1 g experiments significantly complicate data analysis. An electromagnetic levitator has been developed at Auburn University to test containerless processing methods for characterizing the surface tension of high temperature, reactive melts. Recent oscillating drop experiments with nickel samples utilizing electromagnetic levitation in the low-g environment of NASA's KC-135 research aircraft have shown droplet oscillations in the primary mode and at the fundamental frequency. A series of experiments was performed with droplets covering a range of sizes (i.e., mass), and the largest samples exhibited the largest deviations from Rayleigh's simple theory. The smallest samples exhibited oscillatory behavior consistent with Rayleigh's simple theory. An uncertainty analysis showed that the oscillating-drop technique should provide uncertainties in surface tension of ±0.1 to 2.0percnt; depending upon the uncertainty in the mass of the sample.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1022686821870
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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