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  • 2005-2009  (3)
  • 1970-1974  (2)
  • 2005  (3)
  • 1972  (2)
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  • 2005-2009  (3)
  • 1970-1974  (2)
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  • 1
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Asthma is accepted as a disease characterized by airway inflammation, with evidence that airway structural changes, or ‘remodelling’ occurs. There are few studies relating airway physiology, inflammation and remodelling, however. We have carried out a study of inter-relationships between airway inflammation, airway remodelling, reticular basement membrane (RBM) thickening, and bronchial hyper-reactivity (BHR), before and after high-dose inhaled corticosteroid (fluticasone propionate 750 μg b.d.), in a group of relatively mild but symptomatic, steroid naïve asthma patients.Methods Double-blind, randomized, placebo-controlled, parallel group study of inhaled corticosteroid (ICS) in 35 asthmatics, with bronchoalveolar lavage (BAL) and airway endobronchial biopsy (EBB) for inflammatory cell profiles and EBB for airway remodelling carried out at baseline, 3 and 12 months.Results At baseline RBM thickening was related to BAL mast cells and EBB eosinophil counts. In turn baseline log EBB EG2 eosinophil count, log%BAL epithelial cells and log RBM thickness explained 55% of the variability in BHR.Conclusion We provide new information that airway inflammation, remodelling, and BHR in asthma are inter-related and improved by ICS therapy. Our data potentially support the need for early and long-term intervention with ICS even in relatively mild asthmatics, and the need to further assess the potential merit of longitudinal BHR testing in management of some patients, as this may reflect both airway inflammation and remodelling.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Discriminant function analyses of infection parameters of parasitic helminths revealed that abundances of seven helminth species contributed significantly to the delineation of four host populations of winter flounder Pleuronectes americanus from the central and south-west Scotian Shelf and the north-east Gulf of Maine (NAFO subdivision 4WX-5Z). These were adult digeneans, Derogenes varicus, Genolinea laticauda, Steganoderma formosum and Steringophorus furciger, metacercariae of the digenean, Stephanostomum baccatum, and larval nematodes, Anisakis simplex and Hysterothylacium aduncum. The correct classification rate was 84% overall, with Georges Bank (5Z) and Sable Island Bank (4W) winter flounder being the most accurately classified samples at 98 and 88%, respectively. Winter flounder from south-west Nova Scotia (4X), an inshore sample from St Marys Bay and offshore fish from Browns Bank, had the lowest rates of correct classification (76 and 71%, respectively) due, primarily, to cross-misclassification between the two samples. Winter pairwise comparisons of four microsatellite markers identified significant genetic differences between all populations sampled with the Georges Bank population being the most genetically distinct overall, and St Marys Bay and Browns Bank fish being the least dissimilar.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: To explore the population structure of Atlantic halibut Hippoglossus hippoglossus, 160 fish from four locations in the north-west Atlantic (Bay of Fundy, Scotian Shelf, Gulf of St Lawrence and Iceland) were examined for evidence of population structure using 18 microsatellite markers. Pair-wise FST and a model-based cluster analysis revealed no significant differentiation between samples, although uncertainties surrounding Atlantic halibut reproductive behaviour made it difficult to ascertain that only a single breeding population had been sampled at each location
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Journal of solution chemistry 1 (1972), S. 3-16 
    ISSN: 1572-8927
    Keywords: Aqueous ; cyclic ethers ; carbohydrates ; inositols ; apparent molal volume ; apparent molal compressibility ; density
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Apparent molal volumes and compressibilities are reported for dilute aqueous solutions of cyclic ethers, simple carbohydrates, and related polyhydroxy compounds. The results for carbohydrates are considered in the light of two theoretical descriptions of such systems, i.e., the semiideal solution approach of Stokes and Robinson, and the McMillan-Mayer theory ty[e of approach as employed by Kozak, Knight, and Kauzmann. It is concluded that neither model is satisfactory, and that for these solutions a specific hydration model, described in more detail in another paper, is more satisfactory.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2048
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Irradiation of homogenates of etiolated barley leaves with red light resulted in an increase in the levels of gibberellin (GA)-like substances as compared to dark controls. When homogenates were fed with [3H]-GA9 there was as incorporation of the radioactivity into a number of other GA's: this process occurred to a greater extent in red light than in darkness, and could be inhibited by boiling the extract prior to addition of the [3H]-GA9.
    Type of Medium: Electronic Resource
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