Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 1990-1994  (2)
  • 1975-1979
  • 1970-1974  (1)
  • 1993  (2)
  • 1973  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Catecholamine synthetic enzymes of spontaneously hypertensive rats and microbial hypotensive products (1973)
    Springer
    Molecular and cellular biochemistry 1 (1973), S. 107-113 
    Details
    ISSN: 1573-4919
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary 1. Oudenone, an inhibitor of tyrosine hydroxylase, and fasaric acid, an inhibitor of dopamine-β-hydroxylase, both newly described inhibitors of microbial origin showed more pronounced hypotensive effects on spontaneously hypertensive rats than on normotensive Wistar rats. 2. Spontaneously hypertensive rats had about 2-fold highe tyrosine hydroxylase and dopamine-β-hydroxylase activities in adrenal glands, and lower tyrosine hydroxylase activity in mesenteric artery. After adrenalectomy, blood pressure of spontaneously hypertensive rats decreased, and the lower tyrosine hydroxylase activity in mesenteric artery increased to the enzyme level of normotensive Wistar rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01659944
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives (1993)
    Springer
    Journal of neural transmission 92 (1993), S. 125-135 
    Details
    ISSN: 1435-1463
    Keywords: Type A and B monoamine oxidase ; inhibitors ; 6,7-dihydroxytetra-hydroisoquinolines ; salsolinols ; human brain synaptosomal mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline (norsalsolinol) and 1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol), and their N-methylated derivatives were found to inhibit type A and B monoamine oxidase isolated from human brain synaptosomal mitochondria. N-Methyl-norsalsolinol, (R) and (S) enantiomer of salsolinol, and N-methyl-salsolinols inhibited type A monoamine oxidase competitively to the substrate, kynuramine, andR enantiomers were more potent inhibitors thanS enantiomers. The inhibition was reversible. Norsalsolinol induced positive cooperativity toward kynuramine. Both norsalsolinol and N-methyl-norsalsolinol inhibited type B oxidase non-competitively to the substrate, and their K1 values were much higher than those to type A. Types of inhibition of type A monoamine oxidase depended on the enzyme sources. Inhibition of monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines is discussed in relation to their chemical structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01244872
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Changes in monoamine levels in mouse brain elicited by forced-swimming stress, and the protective effect of a new monoamine oxidase inhibitor, RS-8359 (1993)
    Springer
    Journal of neural transmission 94 (1993), S. 175-187 
    Details
    ISSN: 1435-1463
    Keywords: Forced-swimming ; stress model ; brain monoamines ; monoamine oxidase-A inhibitor ; RS-8359
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As a stress model, a forced swimming test was applied to mice; and a typical behavioral change, an immobile posture, was recognized. This affected the brain monoamine levels significantly. The norepinephrine concentration was reduced, while that of its product was increased; and in the case of dopamine, both the amount of the amine and its product were increased. Stress increased the levels of serotonin and its product in the brain. The effects of RS-8359, (±)-4-(4-cyanophenyl)amino-6,7-dihydro-7-hydroxy-5H-cyclopenta[d]-pyrimidine, a new inhibitor of type A monoamine oxidase, on the behavioral and biochemical changes caused by forced swimming were also investigated. RS-8359 significantly improved the immobile posture elicited by the forced swimming test. It reduced the increased turnover of norepinephrine and serotonin systems caused by swimming. These results suggest that the effect of RS-8359 on behavioral and biochemical changes by stress may be mainly due to its effects on norepinephrine and serotonin systems, presumably by the inhibition of type A monoamine oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01277023
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...