Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Journal of neurochemistry
20 (1973), S. 0
ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
A major catabolic route for glycine in liver is its conversion to methylene tetra-hydrofolate (methylene THF), CO2 and NH3, catalysed by the glycine cleavage system described by Yoshida and Kikuchi (1970). In view of the role of glycine as a putative neuro-transmitter, the occurrence of this system in mammalian brain was investigated. Our studies demonstrated: (a) that the production of 14CO2 from [1-14C]glycine required the presence of tetrahydrofolate, NAD, dithiothreitol and pyridoxal phosphate in the reaction mixture; (b) that besides CO2l-serine was the other major product of the reaction; (c) that glyoxylate did not function as an intermediate in this reaction; and (d) that enzymatic activity appeared to be associated with membranes. All of these properties resembled those previously described for the hepatic system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1973.tb00281.x
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