ISSN:
1432-2072
Keywords:
Thyrotropin Releasing Hormone (TRH)
;
Biogenic Amines
;
Catecholamines
;
Norepinephrine
;
Dopamine
;
Serotonin
;
Antidepressants
;
Depression
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Synthetic thyrotropin releasing hormone (TBH) was administered to albino rats in order to determine the effects of this drug on norepinephrine-H3 metabolism in the brain. With the possible exception of a slight enhancement of release, acute or chronic administration of TRH had little effect on the disposition and metabolism of norepinephrine-H3 in rat brain. In addition, no significant changes were found in brain levels of endogenous norepinephrine, serotonin or dopamine following the injection of TRH. Thus, little evidence was found to support a possible relationship between the reported clinical antidepressant activity of TRH and its effects on norepinephrine metabolism in brain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426676
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