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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 364 (1976), S. 135-141 
    ISSN: 1432-2013
    Keywords: Vascular smooth muscle ; Force velocity relation ; pH ; Calcium ; Noradrenaline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The kinetics of vascular smooth muscle activity was studied by means of afterloaded isotonic contractions of the tetanized rat portal vein at varied pH (8.0–5.9), pCa (3.4–2.1), and during noradrenaline incubation (0.4 μg/ml). Under control conditions (pH 7.3, pCa 2.6) the following parameters of the force velocity relation were calculated:a of Hill's equation (relating to the isometric peak tension)=0.36;b (relating to the actual muscle length)=0.19 ML/s;V M (relating to the actual muscle length)=0.56 ML/s. Within the range of pCa between 2.0 and 3.2 the amount of force generation (=ΔP) depended on the extracellular calcium level whereas the extrapolated velocity of shortening of the unloaded preparation (=V M) did not. Also pH changes between 8.0 and 6.8 as well as noradrenaline incubation at a pH of 5.9 affectedΔP quite considerably, butV M only scarcely. At a pH of 6.3, however,V M was distinctly diminished, and a reduced calcium sensitivity of the ATPase was inferred from the shift of ED50 of extracellular calcium from 0.66 mM Ca at a pH of 7.3 to 1.56 mM Ca at a pH of 6.3 (P〈0.0005). It is concluded from these results that the experimental conditions—pCa between 2.0 and 3.2, pH between 8.0 and 6.8, and noradrenaline added at a pH of 5.9—obviously change the intracellular calcium concentration which influences the number of activated interaction sites rather than the velocity of crossbridge movement.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 342 (1976), S. 598-599 
    ISSN: 1435-2451
    Keywords: Endobrachyesophagus (Syndrome, Barrett's) ; Stenosis, peptic esophageal ; Endobrachyoesophagus (Barrett-Syndrom) ; Peptische Oesophagusstenosen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Endobrachyoesophagus ist in aller Regel eine erworbene Zylinderepithelmetaplasie des distalen Oesophagus. Seine angeborene Variante ist sehr selten. Neben der malignen Entartung und dem Ulcus oesophagi ist die peptische Stenose die häufigste Komplikation. Sie entwikkelt sich einmal bei gleichzeitigem Vorliegen eines gastrooesophagealen Refluxes, zum anderen bei Auskleidung des distalen Oesophagus mit säurezernierender Magenschleimhaut. Während im 1. Fall eine Antirefluxoperation, z. B. in Form der Fundoplicatio, durchgeführt werden muß, steht die Reduzierung des Säurepotentials im Oesophagus im 2. Fall im Zentrum der chirurgischen Maßnahmen. Die eigenen Erfahrungen an insgesamt 42 peptischen Stenosen werden dargestellt.
    Notes: Summary Endobrachyesophagus is generally an acquired metaplasia of the columnar epithelium of the distal esophagus. It is very rare in its congenital form. Apart from malignant degeneration and esophageal ulcer, peptic stenosis is the commonest complication. This can develop as a result of the accompanying gastroesophageal reflux or through the lining of the distal esophagus with acid-producing gastric mucosa. While in the first case an antireflux operation, for example fundoplication, must be carried out, in the second case the main purpose of surgery is to reduce acid production in the esophagus. Details of 42 patients with peptic stenosis are set out.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 343 (1976), S. 45-58 
    ISSN: 1435-2451
    Keywords: Esophagojejunoplication ; Total gastrectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Dargestellt werden Indikation, operative Technik und klinische Ergebnisse der Oesophago-Jejunoplicatio.Bei 46 an derChirurgischen Universitätsklinik Göttingen operierten Patienten gab 20mal eine gutartige Grundkrankheit und 26mal ein Magencarcinom die Indikation zur totalen Gastrektomie ab. Wesen der Operationsmethode ist die Bildung einer Jejunummanschette, die um die Anastomose und terminalen Oesophagus gelegt wird. Besonderer Vorteil ist die Anastomosensicherheit; es wurden nur 3 blande verlaufende Insuffizienzen beobachtet (6,5 %). Die Operationsletalität betrug 8,5 %, die Gesamtrate an Komplikationen 26,1%. Bei 30 überlebenden Patienten konnte eine Nachuntersuchung durchgeführt werden, deren Ergebnisse vorgelegt werden. Nur in 7,9% dieser Patienten konnte ein jejunooesophagealer Reflux nachgewiesen werden.
    Notes: Summary Indications, surgical technique, and clinical results in esophagojejunoplication are shown. In 46 patients the indication for total gastrectomy in 20 cases was a benign disease and in 26 cases cancer of the stomach. An essential feature of this method is the construction of a jejunal cuff, which is drawn around the anastomosis and the terminal esophagus. Particular advantage is the security of the anastomosis; we have observed only three leakages and these were without complications (6.5 %). The fatality rate was 8.5 %, and the total rate of complications was 26.1 %. With 30 surviving patients a postoperative follow-up was carried out, the results of which are shown. Jejunoesophageal reflux occurred in only 7.9% of these patients.
    Type of Medium: Electronic Resource
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