ISSN:
1432-1912
Keywords:
Morphine
;
Dopamine
;
Adrenal medulla
;
Plasma catecholamines
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Dopamine (DA) concentrations in rat adrenals, plasma and brain were variably elevated 1 h after a large parenteral dose of morphine. In adrenals, unlabelled DA increased 2-fold and labelled DA, synthesized from 3H-tyrosine, increased more than 4-fold. The increases could be prevented by inhibition of DA-synthesizing enzymes and spinal cord transection, respectively. Labelled DA in plasma increased 2.7-fold after morphine in intact rats but did not increase in those with spinal cord transection. It is concluded that: (1) morphine stimulates the adrenal by increasing nerve impulse flow, (2) increased nerve impulse flow increases DA synthesis and levels, and (3) the increased DA levels result in increased release of DA into the bloodstream.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00508805
Permalink
