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Mobilization of subcutaneously injected tritiated insulin in rats: Effects of muscular exercise (1978)

Berger, M. ; Halban, P. A. ; Muller, W. A. ; [et al.]

Springer

Diabetologia 15 (1978), S. 133-140

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ISSN: 1432-0428

Keywords: Exercise ; tritiated insulin ; subcutaneous insulin injections ; exercise-induced hypoglycaemia

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Previous studies in man and pancreatectomized dogs have indicated that alterations of the pharmacokinetics of subcutaneously injected insulin during physical activity may contribute to exercise-induced hypoglycaemia in insulin-treated diabetic patients. We have directly measured the appearance of subcutaneously injected insulin in the circulation and assessed its distribution to different tissues using a recently developed semisynthetic homogeneous [3H]insulin as a tracer. Following subcutaneous injection in rats of [3H]insulin in amounts insufficient to exert significant biological activity in intact animals, circulating levels of exogenous insulin were measured as plasma radioactivity co-migrating with insulin during gel filtration chromatography. Strenuous treadmill running accelerated the mobilization of subcutaneously injected [3H] insulin and resulted in a significant elevation of circulating levels of exogenous insulin early during exercise, followed by decreased levels in the post-exercise period. In addition, exercise induced a redistribution of 3H radioactivity in tissues, mainly increasing that found in skeletal muscle. This direct demonstration of altered pharmacokinetics of subcutaneously injected insulin during exercise provides, at least in part, a mechanism for the exercise-induced hypoglycemia seen following insulin injections in animals and during insulin treatment in man.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00422259

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Preference for Syn Ene Additions of 1O2 to Trisubstituted, Acyclic Olefins (1978)

Schulte-Elte, Karl H. ; Muller, Bernard L. ; Rautenstrauch, Valentin

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 61 (1978), S. 2777-2783

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ISSN: 0018-019X

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Dye-sensitized photooxygenations of 3 pairs of (E)/(Z) trisubstituted olefins were studied in order to establish the partitioning between the 3 possible ene additions. The (E)-isomers underwent only the 2 ene additions (〉95%) involving H-atom abstractions at the same, disubstituted side of the olefins, termed syn ene additions, with almost equal ease. The (Z)-isomers underwent mainly (85-90%) the syn ene additions, with the ones leading to the tertiary hydroperoxides distinctly favoured, and some (10-15%)ene additions at the monosubstituted side of the olefin, termed anti ene addition.

Additional Material: 1 Tab.