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  • 1990-1994
  • 1980-1984
  • 1975-1979  (3)
  • 1935-1939
  • 1930-1934
  • 1979  (3)
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Material
Years
  • 1990-1994
  • 1980-1984
  • 1975-1979  (3)
  • 1935-1939
  • 1930-1934
Year
  • 1
    Electronic Resource
    Electronic Resource
    Effect of prostaglandin E 2 on prostacyclin production by endothelial cells (1979)
    [s.l.] : Nature Publishing Group
    Nature 278 (1979), S. 480-480 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IT has been suggested by Tomasi et ai1 that prostaglandin (PG) E2 inhibits the synthesis of PGI2 (prostacyclin) by endo-thelial cells. This conclusion was based mainly on their observation that the inhibition of platelet aggregation produced by a suspension of isolated hepatic cells (described as ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/278480a0
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Vascular endothelial and smooth muscle cells in culture selectively release adenine nucleotides (1979)
    [s.l.] : Nature Publishing Group
    Nature 281 (1979), S. 384-386 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The production of PGI2 has previously been demonstrated by the ability of cultured vascular cells to inhibit platelet aggregation induced by a variety of stimuli1'2'8"10. Using porcine aortic endothelial cells in culture11, we showed that PGI2 production was blocked by low concentrations of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/281384a0
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Chemo-adoptive immunotherapy against a guinea-pig leukemia (1979)
    Springer
    Cancer immunology immunotherapy 6 (1979), S. 17-25 
    Details
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Strain-2 guinea-pigs bearing the transplantable L2C leukemia were treated with cytoxan 24 h prior to receiving an injection of either allogeneic or syngeneic spleen cells from donors preimmunized to the leukemia. Treatment with the drug alone produced a remission period which lasted for 4–5 weeks before eventual relapse and death. An IP transfer of spleen or peritoneal exudate (PE) cells from syngeneic strain-2 guinea-pigs hyperimmunized to the leukemia greatly extended the survival times of drug-treated animals beyond that observed in animals receiving normal strain-2 cells. Long-term survivors were refractory to a subsequent challenge with a lethal inoculum of L2C cells. A reduced tumor load was essential for an immunotherapeutic effect of adoptively transferred cells. The use of sensitized lymphocytes alone failed to control the established disease. Hyperimmune spleen cells from strain-13 and Hartley guinea-pigs also demonstrated a slight capacity to inhibit the proliferation of leukemia cells when injected into diseased animals previously treated with the drug. Due to inadequate drug suppression, however, the injection of allogeneic cells from either immune strain-13 or Hartley guinea-pigs did not prolong the latent period for the appearance of the leukemia to the same extent as either immune strain-2 spleen or PE cells. A marked delay in the onset of disease was noted when immune spleen cells from either syngeneic or allogeneic sources were mixed in vitro with L2C leukemia cells at a ratio of 200:1 before injection back into normal strain-2 animals. However, an exposure of L2C blast cells in vitro with heat-inactivated serum obtained from L2C-immune strain-2 animals significantly enhanced the onset of disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00206012
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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