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  • 1
    Electronic Resource
    Electronic Resource
    Amino acids evoke short-latency membrane conductance increase in pancreatic acinar cells (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 492-494 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Two separate KCl-filled microelectrodes were inserted into neighbouring cells in the same acinus of mouse pancreas (under visual control using a Zeiss (Jena) phase contrast microscope (400) with long working distance) in vitro as previously described14,15. Up to two extracellular micropipettes were ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283492a0
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  • 2
    Electronic Resource
    Electronic Resource
    Substance P increases membrane conductance in parotid acinar cells (1980)
    [s.l.] : Nature Publishing Group
    Nature 283 (1980), S. 393-395 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Isolated segments of rat parotid gland were mounted in a tissue bath through which oxygenated physiological saline solutions were circulated at 37 C. Single microelectrodes were used to record both membrane potential and input resistance of surface acinar cells6. Substance P (Peninsula Lab.) was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/283393a0
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  • 3
    Electronic Resource
    Electronic Resource
    Effects of intracellular EGTA injection on stimulant-evoked membrane potential and resistance changes in pancreatic acinar cells (1980)
    Springer
    Pflügers Archiv 386 (1980), S. 147-152 
    Details
    ISSN: 1432-2013
    Keywords: Pancreatic acinus ; Calcium ; Membrane potential ; Membrane resistance ; EGTA ; Stimulus-permeability coupling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Membrane potential and resistance were measured from two neighbouring electrically coupled cells within the same mouse pancreatic acinus, using one electrode filled with KCl and another filled with K-EGTA [ethylene glycol-bis-(β-amino ethyl ether) N,N′-tetra acetic acid] or K-acetate. EGTA was injected into one cell by passing pulses of hyperpolarizing current through the EGTA microelectrode. In order to ensure constant membrane potential, pulses of depolarizing current of the same intensity were simultaneously passed through the other electrode. Intracellular injection of EGTA, but not acetate, decreased significantly the membrane response (depolarization, resistance reduction) of both coupled cells to small microionophoretic pulses of ACh stimulation. Responses to larger doses were decreased to a smaller extent. Intracellular injection of EGTA also decreased significantly the membrane response of both coupled cells to microionophoretic pulses of pentagastrin stimulation. In contrast intracellular injection of EGTA did not inhibit membrane response tol-alanine stimulation.l-Alanine-evoked membrane depolarization was independent of external Ca. This is in contrast to what has previously been shown for secretagogue effects. It is concluded that EGTA-induced sequestration of cytosolic Ca2+ decreases membrane responses to both ACh and pentagastrin, providing new evidence of the crucial role played by internal Ca2+ in mediating stimulus-permeability coupling. In contrast,l-alanine action does not appear to be mediated by internal Ca2+.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584202
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  • 4
    Electronic Resource
    Electronic Resource
    Amino acid-evoked membrane potential and resistance changes in pancreatic acinar cells (1980)
    Springer
    Pflügers Archiv 386 (1980), S. 153-159 
    Details
    ISSN: 1432-2013
    Keywords: l-Amino acids ; Membrane potential ; Membrane resistance ; Pancreatic acinar cell ; Na-conductance ; l-Alanine-amino acid interactions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effect of some neutrall-amino acids, alanine, valine and proline, on the pancreatic acinar cell membrane potential and resistance was investigated. Simultaneous recordings were made with two intracellular microelectrodes on isolated superfused segments of mouse pancreas. Amino acids were applied by inclusion at known concentrations in the superfusion fluid or by microionophoresis from extracellular micropipettes. l-Alanine (10 mmol·l−1) evoked a maximal membrane depolarization of about 18 mV. A just detectable depolarization was observed at 0.1 mmol·l−1 (3 mV). Halfmaximal depolarization was observed at 1.6 mmol·l−1.d-Alanine had virtually no effect. Microionophoretic applications ofl-alanine,l-valine orl-proline evoked depolarization and resistance reduction with a very short delay (〈50 ms). The dose response curves for depolarization and resistance reduction were similar. The amplitude of the depolarization evoked byl-alanine,l-valine andl-proline depended linearly on the level of the pre-set membrane potential (membrane potential could be changed by direct current injection). With decreasing intracellular negativity there was a decrease in the size of the amino acid-evoked depolarization. When the membrane potential was inside positive the amplitude became very small. Extrapolation of the linear relations between membrane potential and size of depolarization revealed a null potential of +20 to +45 mV. Thel-alanine-evoked depolarization was acutely reduced but not abolished by replacing extracellular Na by Tris or Li. l-Alanine,l-proline andl-valine exhibited mutual inhibition of evoked depolarization even when the depolarizing effect of the first applied amino acid was balanced by direct current injection. It is concluded that severall-amino acids act on the pancreatic acinar plasma membrane by opening conductance pathways mainly permeable to Na.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584203
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  • 5
    Electronic Resource
    Electronic Resource
    First occurrence of the rare mineral Barylite in Greenland (1980)
    Springer
    Mineralogy and petrology 27 (1980), S. 35-39 
    Details
    ISSN: 1438-1168
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences
    Description / Table of Contents: Zusammenfassung Der seltene Barylith wurde zum ersten Mal in Grönland in verschiedenen Proben aus Nephelin-Syenit-Pegmatit-Drusen bei Narssârssuk identifiziert. Die Kristalle sind orthorhombisch mit den Formen {100}, {210} und {201}, sie bilden dünne Tafeln nach {100}. Elektronensonden-Analyse und Emissions-Spektrographie ergeben eine chemische Zussammensetzung, die der Idealform nahekommt. Die verfeinerten Zellparameter sind folgende:a=9,835(2) Å,b=11,654(3) Å undc=4,673(1) Å. Barylith ist zweiachsig negativ, 2V α=66o±2o,n α=1,694,n β=1.697 undn γcalc.= 1,698.
    Notes: Summary Barylite has been identified for the first time in Greenland in several specimens from the nepheline syenite pegmatite pockets at Narssârssuk. The crystals are orthorhombic, showing the forms {100}, {210} and {201}, and form thin plates parallel to {100}. Electron microprobe analysis and emission spectrography show a composition close to the ideal formula. The refined unit cell paramters are:a=9.835(2) Å,b=11.654(3) Å andc=4.673(1) Å. The barylite is biaxial negative, 2V α=66o±2o,n α=1.694,n β= 1.697 andn γ calc.=1.698.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01081861
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