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Insulin degradation. XXVIII. Immunocytochemical localization of glutathione-insulin transhydrogenase in the pancreas, kidney and liver of normal and streptozotocin-diabetic rats and of lean and obese (ob/ob) mice (1981)

Taylor, C. A. ; Varandani, P. T.

Springer

Diabetologia 21 (1981), S. 464-469

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ISSN: 1432-0428

Keywords: Immunocytochemistry ; glutathione-insulin transhydrogenase ; thioliprotein-disulphide oxidoreductase ; streptozotocin-diabetic rats ; obese (ob/ob) mice ; pancreatic acini ; islets of Langerhans ; kidney tubules ; liver

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Glutathione-insulin transhydrogenase catalyzes the inactivation of insulin by splitting the hormone into A and B chains. We have localized this enzyme immunocytochemically by light microscopy in the pancreas, kidney and liver of both lean and obese (ob/ob) mice and similarly in normal and streptozotocin-diabetic rats. Localization was achieved by an antibody to glutathione-insulin transhydrogenase using a peroxidase-antiperoxidase technique. In comparison with tissues from control animals, positive immunostaining for glutathione-insulin transhydrogenase was increased in the obese mouse but reduced in the diabetic rat. Different tissues showed considerable variation in the amount of glutathioneinsulin transhydrogenase which could be detected. In the pancreatic islets there was little or no evidence for the presence of the enzyme in peripheral cells. In the kidney, immunocytochemical staining was found only in the proximal tubules. In the liver there was a generalised distribution of the enzyme, but the greatest concentration was in the periportal region. These observations parallel the biochemical data relating to glutathione-insulin transhydrogenase, indicating that different amounts of insulin degrading activity exist in different regions of tissues.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00257787

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Modelling flow over a backward-facing step using the F.E.M. and the two-equation model of turbulence (1981)

Taylor, C. ; Thomas, C. E. ; Morgan, K.

Chichester : Wiley-Blackwell

International Journal for Numerical Methods in Fluids 1 (1981), S. 295-304

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ISSN: 0271-2091

Keywords: Numerical Methods ; Turbulence ; Separation ; Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

Notes: Flow over a downstream-facing step is predicted using the F.E.M. A two-equation model of turbulence is employed where the transport of turbulence kinetic energy and dissipation rate are depicted using transport-type equations, i.e. the two-equation model of turbulence. The results obtained are compared with other models and experimental results. Generally, the model was found to be under-predictive with regard to the reattachment length when previous empirical data was used in the transport equations.

Additional Material: 8 Ill.