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A clinical and pharmacodynamic evaluation of sulpiride (1981)

Rama Rao, V. A. ; Bailey, J. ; Bishop, M. ; [et al.]

Springer

Psychopharmacology 73 (1981), S. 77-80

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ISSN: 1432-2072

Keywords: Double-blind ; Sulpiride ; Haloperidol ; Chronic schizophrenia ; Drug concentration ; Prolactin level ; Clinical effects

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract In a double-blind study the therapeutic efficacy of sulpiride was compared to that of haloperidol — an established neuroleptic agent. A total of 30 female patients with a diagnosis of chronic schizophrenia were initially stabilised on the dosage of haloperidol which produced optimum therapeutic response when given once or twice daily. The patients were then randomly allocated to receive either sulpiride or haloperidol over a period of 12 weeks. Plasma drug concentrations and prolactin levels were determined. Clinical effects were evaluated by Brief Psychiatric Rating Scale (BPRS), Wing Rating Scale, and Extrapyramidal Symptoms Rating Scale (EPS). A standardised side-effects checklist was used. Treatment with sulpiride was associated with a significant rise in plasma prolactin level, but paradoxically these patients had significantly reduced extrapyramidal symptoms. No significant correlation was found between plasma sulpiride concentration and prolactin level or any of the clinical variables. The study confirms the antipsychotic activity of sulpiride.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00431106

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Bacterial population dynamics in batch and continuous-flow microbial reactors (1981)

Nishimura, Y. ; Bailey, J. E.

Hoboken, NJ : Wiley-Blackwell

AIChE Journal 27 (1981), S. 73-81

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ISSN: 0001-1541

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology

Notes: Calculations of the distribution of states in cell populations grown in well-mixed, isothermal batch and continuous flow reactors are presented. By restricting the analysis to a class of bacteria for which cell division control may be modeled using overlapping timers, analytical results are obtained for many cell population characteristics in terms of the growth rate history. This required growth rate trajectory is evaluated using a separate overall reactor model. The simulation results conform qualitatively to available experimental data and suggest new experiments for further testing of the single-cell model.

Additional Material: 5 Ill.