ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Interaction of prolactin and testosterone in the human prostate (1981)

Farnsworth, Wells E. ; Slaunwhite, W. Roy ; Sharma, Minoti ; [et al.]

Springer

Urological research 9 (1981), S. 79-88

add to mindlist on the mindlist

Details

ISSN: 1434-0879

Keywords: Prolactin ; Prostate cancer ; Benign prostatic hyperplasia ; Androgen metabolism

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Three experiments were performed to determine whether human prolactin (hPr) affects prostatic uptake and metabolism of testosterone (T). 1) Patients with prostatic cancer were infused twice with radio-labelled androgens, the first time with basal hPr, the second time with oral thyrotrophin-releasing hormone (TRH)-elevated hPr. In 5/7, significant increases in metabolic clearance of dihydrotestosterone (DHT) and in conversion of T to DHT accompanied increased hPr. 2) The incorporation of labelled T into minced benign prostatic hypertrophy (BPH) tissue from subjects with high (40 ng/ml) hPr was measured and was found to be more than twice the uptake into tissue from those with low hPr (6.5±1.9 ng/ml). 3) Uptake and metabolism in vivo of a bolus of 3H-T by BPH and carcinomatous prostates was measured and was far greater in subjects whose hPr was elevated by chlorpromazine than in untreated controls. It is concluded that prolactin increases prostatic uptake and metabolism of T. It is suggested that the best management of prostatic cancer should include depletion of prolactin as well as androgen.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00256681

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Observations on preadipocytes and their distribution patterns in rat adipose tissue (1981)

Askew, E. W. ; Schuschereba, S. T. ; Brown, J. P. ; [et al.]

New York, NY : Wiley-Blackwell

Journal of Morphology 168 (1981), S. 281-288

add to mindlist on the mindlist

Details

ISSN: 0362-2525

Keywords: Life and Medical Sciences ; Cell & Developmental Biology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Medicine

Notes: Microscopic examination of adipocytes isolated from adult rat epididymal adipose tissue revealed numerous small cells (〈 10 μm) morphologically similar to larger adipocytes. These small adipocytes appear identical to a new classification of adipose cells termed preadipocytes. Electron micrographs of these preadipocytes revealed examples of cells 〈 10 μm in diameter in various stages of maturation and lipid accumulation. The percent distribution pattern of these small adipocytes was not significantly altered by exercise although exercise shifted the distribution patterns of the larger cells (〉 30 μm) toward a smaller mean cell size. The quantitative significance of preadipocytes is not established but these preliminary observations indicate that adipocytes 〈 10 μm in diameter may account for a numerically greater proportion of the total adipocytes observed in collagenase isolated preparations than heretofore recognized, although their contribution to total adipose mass is probably negligible.

Additional Material: 9 Ill.