Electronic Resource
Oxford, UK
:
Blackwell Publishing Ltd
Clinical and experimental pharmacology and physiology
8 (1981), S. 0
ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. Individual anterior hypothalamic-preoptic nuclei were dissected from the brains of control and α-methyldopa treated (2 × 40 mg/kg, 5 days) rats, and the concentrations of adrenaline and other catecholamines were estimated.2. By a combination of radioenzymatic assay and paper chromatography the concentrations of adrenaline, noradrenaline, dopamine, α-methylnoradrenaline and α-methyldopamine were determined concurrently in the same sample.3. α-Methyldopa reduced the adrenaline levels of the hypothalamic nuclei by 47–68% of control concentrations.4. A differential displacement of the parent catecholamines was observed and the depletions were ranked: adrenaline 〈 dopamine 〈 noradrenaline.5. α-Methylnoradrenaline and α-methyldopamine were found in all hypothalamic nuclei.6. The depletion of hypothalamic adrenaline by α-methyldopa could represent a pharmacological mechanism contributing to the antihypertensive action of the drug.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1981.tb00130.x
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