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  • 1980-1984  (3)
  • 1984  (2)
  • 1982  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Gradient liquid chromatography/mass spectrometry using microbore columns and a moving belt interface (1984)
    s.l. : American Chemical Society
    Analytical chemistry 56 (1984), S. 1229-1236 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac00272a009
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Two keratins MW 50,000 and 56,000 are synthesized by psoriatic epidermis (1984)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 111 (1984), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The keratin polypeptide composition of uninvolved psoriatic epidermis is the same as normal epidermis. In contrast, involved epidermis from psoriasis contains significant amounts of two keratin polypeptides, molecular weight (MW) 56 and 50 kilodaltons (KD). Involved epidermis contains decreased amounts of keratins MW 69, 66·5 and 65·2 KD. Slices of involved psoriatic epidermis incorporate [35S]methionine into all the keratins including those of MW 56 and 50 KD. Unexpectedly, we found that [35S]methionine is incorporated into 56 and 50 KD keratins in uninvolved epidermis even though these keratins are not abundant enough to be seen in Coomassie stained gels. The two-dimensional patterns of iodinated tryptic peptide digests of keratin MW 50 KD from uninvolved, involved and normal epidermis arc identical. We conclude that keratins of MW 56 KD and 50 KD are abundant in involved psoriatic epidermis. They are not present in normal or uninvolved psoriatic epidermis, but are rapidly synthesized when normal epidermis (neonatal foreskin) or uninvolved psoriatic epidermis are removed and placed in organ culture. The two keratins may be markers of increased cell proliferation or injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1984.tb15579.x
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Bromperidol, a new butyrophenone neuroleptic: A review (1982)
    Springer
    Psychopharmacology 78 (1982), S. 1-7 
    Details
    ISSN: 1432-2072
    Keywords: Bromperidol ; Haloperidol ; Chlorpromazine ; Preclinical review ; Animal pharmacology ; Animal pharmacokinetics ; Animal biotransformation ; Animal drug safety
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This review compares and contrasts the preclinical pharmacology of bromperidol with another butyrophenone neuroleptic, haloperidol, and the phenothiazine neuroleptic chlorpromazine. Its pharmacokinetics, biotransformation, and safety in several laboratory animal species are also summarized. These preclinical data support its use as an antipsychotic agent and show that it is well absorbed following oral administration with an apparent elimination half-life of approximately 24 h, supporting a once-daily dose regimen. Animal toxicity (including acute- and multiple-dose toxicology and reproductive and mutagenicity studies) show that bromperidol is well tolerated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00470578
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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