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  • 2000-2004  (1)
  • 1990-1994
  • 1980-1984  (1)
  • 1910-1914
  • 2000  (1)
  • 1982  (1)
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  • 2000-2004  (1)
  • 1990-1994
  • 1980-1984  (1)
  • 1910-1914
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  • 1
    Electronic Resource
    Electronic Resource
    Diet in late pregnancy and glucose-insulin metabolism of the offspring 40 years later (2000)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 107 (2000), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Objective To determine how diets of women in pregnancy influence the glucose-insulin metabolism of their offspring in adult life.Design A follow up study of men and women born during 1948–1954 whose mothers had taken part in a survey of diet in late pregnancy.Setting Aberdeen, Scotland.Population One hundred and sixty-eight men and women born in the Aberdeen Maternity Hospital.Main outcome measure Plasma glucose and insulin concentrations, fasting and after a standard oral glucose challenge.Results The offspring of women who had high intakes of fat and protein in late pregnancy had a reduced plasma insulin increment between fasting and 30 min with a 7.0% decrease in increment (P= 0.007) per 10 g increase in protein intake and a 4.9% decrease (P= 0.002) per 10 g increase in fat intake. This was independent of the mother's body mass index or weight gain in pregnancy. A low maternal body mass index in early or late pregnancy was associated with a raised fasting plasma insulin concentration with a decrease of 2.4% (P= 0.05) per 1 kg/m2 increase of maternal body mass.Conclusion High intakes of protein and fat during pregnancy may impair development of the fetal pancreatic beta cells and lead to insulin deficiency in the offspring. The offspring of thin mothers tend to be insulin resistant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.2000.tb11088.x
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  • 2
    Electronic Resource
    Electronic Resource
    Incidence of diabetes amongst people aged 18–50 years in nine British towns: A collaborative study (1982)
    Springer
    Diabetologia 22 (1982), S. 421-425 
    Details
    ISSN: 1432-0428
    Keywords: Incidence of Type 2 diabetes ; socio-economic environment ; social class
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The incidence of diabetes among people aged 18–50 years has been studied prospectively in nine towns, chosen to encompass the range of socioeconomic conditions and spread of latitude in England and Wales. The incidence of Type 1 (insulindependent) diabetes in this age group varied little between the towns. However, the incidence of Type 2 (non-insulin-dependent) diabetes was markedly higher in the towns with ‘worse’ socio-economic conditions. The mean incidences were 23 per 100000 for the three ‘worse’ towns and 10 per 100000 for the three ‘better’ towns. This was not explicable by an association between the disease and social class. This finding has to be reconciled with known and hypothesised influences in the aetiology of Type 2 diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00282583
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    Paper (German National Licenses)
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