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  • 1980-1984  (2)
  • 1982  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 78-80 
    Details
    ISSN: 1432-0533
    Keywords: Intracytoplasmic acidophilic granules ; Melanin-bearing neurons ; Round electron-dense body ; Mitochondrial inclusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using the brains of 30 patients with mental and neurologic disorders, we studied the intracytoplasmic acidophilic granules in neurons of the substantia nigra and locus ceruleus by light and electron microscopy. The granules were present in all 30 brains, including those with no recognizable pathologic change, there was no correlation between their appearance and the age, sex, disease of, or the medication received by, the patients. In four electron-microscopically examined brains, we noted many small, round electron-dense bodies in the perikarya and neuronal processes of the substantia nigra and locus ceruleus. The bodies were packed tightly within a double membrane; in shape, size, and distribution in the neuronal cytoplasm, they corresponded to acidophilic granules. Some mitochondrial matrices contained one or more similar, but smaller inclusion bodies; larger bodies pushed aside the mitochondrial cristae. We conclude that the acidophilic granules represent highly developed forms of mitochondrial inclusions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691186
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Localization of tRNA genes of Drosophila melanogaster by in situ hybridization (1982)
    Springer
    Chromosoma 86 (1982), S. 279-292 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Six purified tRNAs labeled with 125I by chemical or enzymatic methods were hybridized to polytene chromosomes of Drosophila melanogaster. The main chromosomal regions of hybridization were: tRNA GGA Gly , 58A, 84C, and 90E; tRNA 2 Leu , 44E, 66B5-8, and 79F; tRNA 2b Ser , 86A, 88A9-12, and 94A6-8; tRNA 3 Thr , 47F and 87B; tRNA 4 Thr , 93A1-2; and tRNA 1γ Tyr , 19F, 22F-23A, 41, 50C1-4 and 85A. At 50C the hybridization of tRNA 1γ Tyr was polymorphic in the giant strains. When the hybridization of three valine isoacceptors studied previously was re-investigated, it was found that only one hybridization site, 90BC, was shared between tRNA 3b Val and tRNA 4 Val . tRNA 3a Val did not have any sites in common with the other two.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00288682
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    Paper (German National Licenses)
    Fulltext
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