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  • 1980-1984  (2)
  • 1975-1979
  • 1920-1924
  • 1983  (2)
  • Distribution  (1)
  • Electron microscopy  (1)
  • 1
    Electronic Resource
    Electronic Resource
    On the ultrastructure of the gastric “borderline lesion” (1983)
    Springer
    Journal of cancer research and clinical oncology 105 (1983), S. 285-291 
    Details
    ISSN: 1432-1335
    Keywords: Borderline lesion ; Severe dysplasia ; Gastric precancerosis ; Electron microscopy ; Morphometric analysis ; Bleb formation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The “borderline lesion” of the stomach (severe dysplasia of the protruded type) is nowadays considered to be a true precancerous lesion. Histologically, this lesion is characterized by a proliferation in the area of the glandular neck, combined with severe cellular atypia. Investigation by means of transmission electron microscopy reveals the structure of these cells to be very similar to the structure of cells of an intestinal-cell-type carcinoma of the stomach. In addition to signs for a loss of differentiation of the cells, such as the absence of rough-surfaced endoplasmatic reticulum, mucin granules, and of the polarity of the cells, remarkably frequently luminal bulges and “blebs” developed to various extents can be detected. Morphometric analysis is delineating the tendency of structural features of the borderline lesion to develop toward the gastric cancer cell. These irregularities might be expressions of the beginning of expansive growth and signs pointing to differentiation into malignant neoplasia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395760
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Distribution of acetylcholine-sensitivity in frog slow muscle fibres (1983)
    Springer
    Pflügers Archiv 397 (1983), S. 300-305 
    Details
    ISSN: 1432-2013
    Keywords: Slow muscle fibres ; ACh ; Sensitivity ; Distribution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract 1) The distribution of acetylcholine-sensitive membrane areas in slow muscle fibres of pyriformis muscles of Rana temporaria was examined by iontophoretic application of acetylcholine from high resistance pipettes. 2) ACh-sensitivity varied considerably along individual slow fibres and from fibre to fibre. In some fibres the sensitivity was restricted to segments of less than 100 μm, in others it was continuous over several millimeter. Segments of variable length, but up to several millimeter, were completely insensitive to acetylcholine. Highly sensitive spots (〉1,000 mV/nC) were found occasionally, their diameter being of the order of 10–20 μm only. The occurrence at rather regular intervals of ACh-sensitive areas was a rare observation; no evidence was found for a generalized ACh-sensitivity. 3) There were marked differences in the lengths of ACh-sensitive segments between surface fibres and fibres located in deeper layers of the muscles. 4) It is concluded that the ACh-sensitive membrane areas correspond to individual nerve muscle contacts of the small motor system whose spatial distribution is extremely variable. In superficial slow fibres the synaptic contacts seem to be located predominantly on the internal circumference of the fibres.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00580265
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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