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  • 1995-1999  (9)
  • 1980-1984  (7)
  • 1960-1964
  • 1955-1959
  • 1995  (9)
  • 1984  (7)
  • 1
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Some cases of autosomal-dominant familial amyotrophic lateral sclerosis (FALS) have been associated with mutations in SOD1, the gene that encodes Cu/Zn superoxide dismutase (Cu/Zn SOD). We determined the concentrations (µg of Cu/Zn SOD/mg of total protein), specific activities (U/µg of total protein), and apparent turnover numbers (U/µmol of Cu/Zn SOD) of Cu/Zn SOD in erythrocyte lysates from patients with known SOD1 mutations. We also measured the concentrations and activities of Cu/Zn SOD in FALS patients with no identifiable SOD1 mutations, sporadic ALS (SALS) patients, and patients with other neurologic disorders. The concentration and specific activity of Cu/Zn SOD were decreased in all patients with SOD1 mutations, with mean reductions of 51 and 46%, respectively, relative to controls. In contrast, the apparent turnover number of the enzyme was not altered in these patients. For the six mutations studied, there was no correlation between enzyme concentration or specific activity and disease severity, expressed as either duration of disease or age of onset. No significant alterations in the concentration, specific activity, or apparent turnover number of Cu/Zn SOD were detected in the FALS patients with no identifiable SOD1 mutations, SALS patients, or patients with other neurologic disorders. That Cu/Zn SOD concentration and specific activity are equivalently reduced in erythrocytes from patients with SOD1 mutations suggests that mutant Cu/Zn SOD is unstable in these cells. That concentration and specific activity do not correlate with disease severity suggests that an altered, novel function of the enzyme, rather than reduction of its dismutase activity, may be responsible for the pathogenesis of FALS.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 186-190 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 31 (1995), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: : During the latter part of the 19th century and the early part of the 20th century, a major cycle of erosion, arroyo cutting, and gullying occurred in the southwestern United States. Since this erosion cycle began, many projects to control erosion, such as the Civilian Conservation Corps projects in the 1930s, were initiated. However, in the Southwestern United States few studies have documented the effect of these structures in reducing erosion or their effect on gully systems. As part of a watershed rehabilitation project on the Zuni Reservation, New Mexico, 47 structures made either of earth or rocks and 23 rock and brush structures were assessed. Sixty percent of the 47 earth or rock structures have breached and relative to dam height, 65 percent of 47 structures are more than 50 percent silted. Of the 23 rock and brush structures, 22 percent have breached or are close to breaching. Reasons for breaching of all structural types may be piping, scour immediately below the structures, large runoff and large drainage area, poor maintenance, headcutting, and active arroyo deepening and widening. In most cases, documentation does not exist on structure design, the specific purpose for a structure, or when these structures were built.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Australasian journal of dermatology 25 (1984), S. 0 
    ISSN: 1440-0960
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Psoriasis among full-blood Australian Aborigines appears to be rare or absent. After examination of some three thousand of these people in central, northern, and southern Australia, I have not seen psoriasis. Other medical and nursing observers have also not seen psoriasis in these people. Two references in the literature to psoriasis in Abotigines are reviewed briegly. The author has seen only one, male, part-Aborigine (more Causcasian than Aborigine), with in a female Aborigine whose father was said to be “not tribal”. A third was recently reported to me.Other conditions common among Aborigines, which should not be confused with psoriasis, are outlined, Certain aspects of the apparent absence of psoriasis in full-blood Australian Aborigines are discussed.Previous research about the essential causes of psoriasis has not been particularly rewarding. An important question must, therefore, be asked. Should some research projects in future be directed to reasons why some human groups seem not to get psoriasis rather than to why others do?
    Type of Medium: Electronic Resource
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  • 5
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    New York : Periodicals Archive Online (PAO)
    Population and environment. 7:2 (1984:Summer) 87 
    ISSN: 0199-0039
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: SPECIAL ISSUE ON ATTACHMENT TO PLACE
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  • 6
    ISSN: 1432-0827
    Keywords: Aluminum ; Parathyroid hormone ; Bone ; Renal failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Bone aluminum, quantitative bone histology, and plasma parathyroid hormone (PTH) were compared in 29 patients undergoing chronic hemodialysis. Histologic techniques included double tetracycline labeling and histochemical identification of osteoclasts and osteoblasts. Bone aluminum was measured chemically by flameless atomic absorption spectrophotometry, and histochemically. When measured chemically, the bone aluminum was 67±46 (SD) mg/kg dry weight (normal 2.4±1.2 mg/kg); histochemically, aluminum was present at 2.9±4.4% of trabecular surface. The biochemical and histochemical results agreed well (r=0.80,P〈0.001). No double tetracycline labels were seen at the mineralization front where aluminum was deposited, indicating cessation of mineralization at these sites. The osteoblast surface correlated positively with plasma PTH (r=0.67,P〈0.001) and negatively with bone aluminum level (r=−0.42,P〈0.05). Multiple linear regression showed a correlation of aluminum with osteoblasts additional to that of PTH, consistent with a direct effect of aluminum in depressing osteoblast numbers. Though a relationship between PTH and chemically determined bone aluminum level could not be demonstrated, there was a negative correlation between osteoclast count and aluminum, and the nine patients with severe hyperparathyroid bone disease had lower chemically determined aluminum levels than the other patients. These results suggest that aluminum (a) directly inhibits mineralization, (b) is associated with decreased PTH activity and hence osteoblast numbers, and (c) directly reduces osteoblast numbers. In addition to inducing severe, resistant osteomalacia, aluminum appears to contribute to the mild osteomalacia commonly seen in renal failure, characterized by extensive thin osteoid and low tetracycline and osteoblast surfaces.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-2072
    Keywords: GM1 ; Haloperidol ; Glutamate synapses ; Perforated PSD ; Striatum ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Haloperidol, a typical antipsychotic drug, causes an increase in the mean percentage of synapses within the striatum containing a discontinuous, or perforated, postsynaptic density (PSD) following 1 month of treatment (Meshul et al. 1994). This effect is not observed with the atypical antipsychotic drug, clozapine, following subchronic administration (Meshul et al. 1992a). This morphological change is also associated with an increase in the density of dopamine D2 receptors. The synapses containing the perforated PSD are asymmetrical and the nerve terminals contain the neurotransmitter, glutamate, as demonstrated by immunocytochemistry. We have also shown that subchronic treatment with haloperidol (0.5 mg/kg per day, 30 days) results in a decrease in the density of glutamate immunoreactivity within asymmetric nerve terminals associated with perforated and non-perforated PSDs (Meshul and Tan 1994). This could be due to an increase in glutamate release, perhaps due to activation of corticostriatal synapses. Agnati et al. (1983a) reported that administration of GM1 ganglioside blocks the increase in dopamine D2 receptors following haloperidol treatment. GM1 has also been shown to attenuate the release of glutamate (Nicoletti et al. 1989). In order to determine if similar treatment with ganglioside could block the haloperidol-induced ultrastructural changes noted above, rats were coadministered GM1 (10 mg/kg per day) and haloperidol (0.5 mg/kg per day) for 30 days. We report that GM1 blocked the haloperidol-induced increase in striatal asymmetric synapses containing a perforated PSD, but had no effect on the increase in dopamine D2 receptors or the decrease in nerve terminal glutamate immunoreactivity. GM1, either alone or co-administered with haloperidol, also caused a small, but significant, increase in the density of all asymmetric synapses within the striatum. It is possible that the effect of GM1 in attenuating the haloperidol-induced change in glutamate synapses with perforated PSDs is primarily postsynaptic, since GM1 did not block the change in density of glutamate immunoreactivity within asymmetric nerve terminals.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Population and environment 7 (1984), S. 87-102 
    ISSN: 1573-7810
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Sociology
    Notes: Abstract This study analyzes neighborhood attachment and satisfaction within the foundations of preference theory—that is, utility analysis. This framework considers an individual's utility function, a construct that relates attachment and satisfaction to the consumption of goods and services. We demonstrate that utility functions can help to predict the individual's bond to the neighborhood. The sample population includes 268 elderly Jews residing in the Baltimore metropolitan area. Bonds to place increase with increasing age. Bonds decrease when residents perceive the neighborhood to be unsafe during the day. The percentage of Blacks is a significant predictor of bonds to place.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1573-689X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The basic physical measurements for determining gas exchange are difficult to make accurately even in a well-equipped, human-performance laboratory with experienced personnel. A fully automated system has been developed to achieve the accuracy of standard laboratory measurements. The application of this instrument extends from critical care to stress-testing. Real-time, multitasking software integrates the data collected from several transducers and analyzers and calculates up to several dozen physiological variables, which are range-checked for reasonableness. The operator is provided with user-friendly means to tailor the data-reporting and-collection functions of the system to his own needs and requirements. Because the instrument is controlled by software, the functions of calibration, measurement, timing, reporting, plotting, and data quality assurance are highly cost-effective. Extensive use of formal test procedures permits verifying all systems and data reliability; it also assures meeting the desired specifications. The ease of operation and high-quality results inherent in this system make it unsurpassed in gas-exchange measurements.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Fermilab experiment E735 located at the CO intersection region of the $$\sqrt s = 1.8$$ TeV $$p\bar p$$ collider analysed over 900 Φ→K + K − events. Measured were the transverse momentum spectrum, the correlation between the average transverse momentum 〈pt〉 and the charged particle multiphcityN c , as well as the probability of Φ production per charged track,N Φ /N c , versusN c . We have also made an estinate of the total inclusive cross section for Φ mesons, $$\sigma (p\bar p \to \phi X) = 7.3 \pm 2.2 mb$$ .
    Type of Medium: Electronic Resource
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