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  • 1
    Electronic Resource
    Electronic Resource
    Absorption of elastase through the jejunal mucosa of the rat (1984)
    Springer
    Histochemistry and cell biology 81 (1984), S. 427-433 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to reveal the absorption process of elastase from the intestine, hog pancreatic elastase was injected into the ligated jejunum lumen of the rat, and the tissues were cytochemically observed at various times after injection. The peroxidase anti-peroxidase (PAP) method using anti-hog-elastase rabbit antibody was used for light microscopy, and the anti-elastase Fab′-peroxidase conjugate was used for electron microscopy. The tissues stained by the PAP method exhibited a dense deposition of reaction products on the luminal surface of epithelial cells and a moderate deposition in the blood and lymph capillaries of the intestinal villi. Immunoelectron microscopy revealed that the reaction product was deposited on the surface of the microvilli and in their pocketing; some was found in the pinocytotic vesicles in the terminal-web area and on the inner surface of the enlarged smooth endoplasmic reticulum. Round droplets which gave a positive reaction were found in the widened intercellular cleft and the thick basement membrane lining the blood capillaries and lymphatics. The jejunum retained its normal ultrastructure. The results indicate that the elastase molecules, which were introduced into the rat jejunum lumen, were absorbed without being decomposed through healthy intestinal epithelial cells by pinocytosis and translocated into blood and lymph capillaries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00489745
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  • 2
    Electronic Resource
    Electronic Resource
    Hyperosmolarity response of ocular standing potential as a clinical test for retinal pigment epithelium activity rhegmatogenous retinal detachment (1984)
    Springer
    Documenta ophthalmologica 57 (1984), S. 175-180 
    Details
    ISSN: 1573-2622
    Keywords: retinal detachment ; standing potential ; hyperosmolarity response ; light peak/dark trough (L/D) ratio ; electro-oculogram (EOG)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hyperosmolarity response of the ocular standing potential was recorded in unilateral rhegmatogenous retinal detachment (8 eyes) and in the fellow ‘healthy’ eye (8 eyes). The hyperosmolarity response was greatly suppressed (M-4 SD: M and SD indicate respectively the mean and the standard deviation in normal subjects) in all affected eyes (p 〈 0.005), and slightly abnormal in 2 fellow eyes. The L/D ratio was normal in 2 affected eyes and in all fellow eyes. The hyperosmolarity response in the affected eyes was still greatly suppressed 14 months after successful surgical treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00143081
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Hyperosmolarity response of ocular standing potential as a clinical test for retinal pigment epithelium activity chorioretinal dystrophies (1984)
    Springer
    Documenta ophthalmologica 57 (1984), S. 163-173 
    Details
    ISSN: 1573-2622
    Keywords: retinal pigment epithelium (RPE) ; standing potential ; hyperosmolarity response ; retinitis pigmentosa ; central and pericentral retinitis pigmentosa ; pigmented paravenous retinochoroidal atrophy ; fundus albipunctatus ; Stargardt's disease ; fundus flavimaculatus ; light peak/dark trough (L/D) ratio ; Diamox response ; electro-oculogram(EOG)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hyperosmolarity response of the standing potential was recorded in retinitis pigmentosa (20 eyes), central (pericentral) retinitis pigmentosa (4 eyes), pigmented paravenous retinochoroidal atrophy (2 eyes), fundus albipunctatus (8 eyes), and Stargardt's disease (or fundus flavimaculatus) (14 eyes). The light peak/dark trough ratio (the L/D ratio) and the Diamox response were also determined. The hyperosmolarity response was greatly suppressed (less than M-4SD; M and SD indicate respectively the mean and the standard deviation in normal control subjects) in all examined eyes with retinitis pigmentosa (20 eyes) including retinitis pigmentosa sine pigmento (8 eyes), central (pericentral) retinitis pigmentosa (4 eyes), and pigmented paravenous retinochoroidal atrophy (2 eyes). The L/D ratio was larger than 1.26 (M-2.5 SD) in the half of the eyes with the above-described diseases. The hyperosmolarity response was abnormal (less than M-2 SD) in 4 of 8 eyes with fundus albipunctatus. The L/D ratio was normal in all 8 eyes. The hyperosmolarity response was abnormal (less than M-2 SD) in all 14 eyes with Stargardt's disease or fundus flavimaculatus. The L/D ratio was abnormal in 5 of these 14 eyes. The hyperosmolarity response was more frequently abnormal than the L/D ratio in the chorioretinal dystrophies mentioned above, and hence is useful particularly for early diagnosis of these disorders.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00143080
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  • 4
    Electronic Resource
    Electronic Resource
    Hyperosmolarity response of ocular standing potential as a clinical test for retinal pigment epithelium activity Diabetic retinopathy (1984)
    Springer
    Documenta ophthalmologica 58 (1984), S. 375-384 
    Details
    ISSN: 1573-2622
    Keywords: diabetic retinopathy ; standing potential ; hyperosmolarity response ; Diamox response ; light peak/dark trough (L/D) ratio ; electro-oculogram (EOG)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The hyperosmolarity response, a drug-induced response from the retinal pigment epithelium, was recorded in diabetic retinopathy. The hyperosmolarity response was occasionally abnormal at the pre-retinopathic stage and at the first stage of retinopathy by Scott classification. The response was frequently abnormal at the second and third stages of retinopathy. The hyperosmolarity response is useful for early diagnosis of pigment epitheliopathy in diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00679800
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  • 5
    Electronic Resource
    Electronic Resource
    Hyperosmolarity response of ocular standing potential as a clinical test for retinal pigment epithelium activity normative data (1984)
    Springer
    Documenta ophthalmologica 57 (1984), S. 153-162 
    Details
    ISSN: 1573-2622
    Keywords: retinal pigment epithelium (RPE) ; ocular standing potential ; hyperosmolarity response ; electro-oculogram (EOG)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The standing potential of the eye is decreased by intravenous administration of hypertonic solutions. This hyperosmolarity-induced response has been recorded in normal subjects by the use of electro-oculography (EOG) in the dark. An intravenous administration of Fructmanit® (1.4 × 103 mOsmol) (150 ∼ 500ml, 2.37 ∼ 9.70ml/kg, 0.08 ∼ 0.36 ml/kg/min) was used to evoke the hyperosmolarity response. The amplitude of the response was expressed in percentage, V0 − Vmin/V0 × 100, where V0 is the base value of the EOG before administration of the hypertonic solution and Vmin is a minimum EOG amplitude after administration. The distribution of the amplitude of the hyperosmolarity response was approximated by the normal distribution in normal subjects. The minimum, the maximum, the mean and the standard deviation of the amplitude of the hyperosmolarity response were respectively 34.2%, 52.3%, 42.6% and 4.6% in normal subjects. The normal range of the hyperosmolarity response would be 33.4 ∼ 51.8% (M ± 2SD). The hyperosmolarity response, which originates mainly in the retinal pigment epithelium, is a useful new quantitative and specific test of the activity of the retinal pigment epithelium in clinical practice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00143079
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