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  • 1980-1984  (2)
  • 1984  (2)
  • Sex pheromone  (1)
  • cirrhosis  (1)
  • Salt tolerance
  • Torpedo marmorata
  • 1
    Electronic Resource
    Electronic Resource
    Naproxen disposition in patients with alcoholic cirrhosis (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 291-296 
    Details
    ISSN: 1432-1041
    Keywords: naproxen ; cirrhosis ; pharmacokinetics ; protein binding ; nonsteroidal antiinflammatory drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Chronic liver disease is known to alter the absorption and disposition of many drugs. To assess the influence of chronic alcoholic liver disease on the disposition of naproxen, we administered the drug both as a single dose and to steady state to 10 individuals with alcoholic cirrhosis and to 10 healthy controls. Plasma and serum samples collected after naproxen dosing were assayed for both total and (following equilibrium dialysis) unbound drug concentration. Clearance calculated based on both total and unbound naproxen concentration revealed no change in total plasma clearance of the drug at steady state but a marked reduction of approximately 60% in clearance based on unbound drug. Naproxen volume of distribution changed only minimally. Because clearance based on unbound drug concentration at a given dosing rate determines the plasma or blood free drug concentration, this concentration may increase significantly in patients with alcoholic liver disease given usual doses of naproxen. Unbound drug concentration is thought to determine the pharmacologic effect of a drug. We therefore recommend that naproxen dosing be reduced by at least half in patients with chronic alcoholic liver disease. In the absence of data to the contrary, this recommendation can be extended to individuals with other forms of hepatic disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542162
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Ethyl (Z)-9-hexadecenoate a sex pheromone ofSyndipnus rubiginosus, a sawfly parasitoid (1984)
    Springer
    Journal of chemical ecology 10 (1984), S. 291-300 
    Details
    ISSN: 1573-1561
    Keywords: Sex pheromone ; Hymenoptera ; Ichneumonidae ; Syndipnus rubiginosus ; ethyl (Z)-9-hexadecenoate ; parasitoid ; Pikonema alaskensis ; mass spectra ; ozonolysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A female-produced sex pheromone ofSyndipnus rubiginosus Walley (Hymenoptera: Ichneumonidae), a parasitoid of the yellowheaded spruce sawfly,Pikonema alaskensis (Rohwer) (Hymenoptera: Tenthredinidae), was isolated and identified from hexane extracts of 250 virgin females. Column chromatography (Florisil), gas chromatography, mass spectrometry, high performance liquid chromatography, and ozonolysis indicated the structure was ethyl (Z)-9-hexadecenoate. The optimum male response is at 300–1000 ng (3–10FE). No cross-attraction betweenS. rubiginosus and the sympatric sawfly parasitoidS. gaspesianus (Provancher) could be demonstrated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00987857
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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