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  • 1990-1994  (2)
  • 1985-1989  (2)
  • 1950-1954
  • 1910-1914
  • 1990  (2)
  • 1985  (2)
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  • 1990-1994  (2)
  • 1985-1989  (2)
  • 1950-1954
  • 1910-1914
Year
  • 1
    Electronic Resource
    Electronic Resource
    Paternal origin of new mutations in Von Recklinghausen neurofibromatosis (1990)
    [s.l.] : Nature Publishing Group
    Nature 343 (1990), S. 558-559 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fourteen three-generation families were identified in which a new mutation to NF-1 had occurred in a single individual in the second generation. DNA typing of these families for loci closely linked to NF-1 (results summarized in Table 1 and Fig. 1) showed that in 12 of the 14 cases, it was ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/343558a0
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    The achondroplasia gene is not linked to the locus for neurofibromatosis 1 on chromosome 17 (1990)
    Springer
    Human genetics 〈Berlin〉 85 (1990), S. 12-14 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We have investigated genetic linkage of von Recklinghausen neurofibromatosis (NF1) and achondroplasia (ACH) using chromosome-17 markers that are known to be linked to NF1. Physical proximity of the two loci was suggested by the report of a patient with mental retardation and the de novo occurrence of both NF1 and ACH. Since the chance of de novo occurrence of these two disorders in one individual is 1 in 600 million, this suggested a chromosomal deletion as a single unifying molecular event and also that the ACH and NF1 loci might be physically close. To test this, we performed linkage analysis on a three-generation family with ACH. We used seven DNA probes that are tightly linked to the NF1 locus, including DNA sequences that are known to flank the NF1 locus on the centromeric and telomeric side. We detected two recombinants between the ACH trait and markers flanking the NF1 locus. In one recombinant, the flanking markers themselves were nonrecombinant. Multi-point linkage analysis excluded the ACH locus from a region surrounding the NF1 locus that spans more than 15cM (lod score 〈 -2). Therefore, analysis of this ACH pedigree suggests that the ACH locus is not linked to the NF1 locus on chromosome 17.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00276318
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Analysis of dynamic mixed-mode isochromatics (1985)
    Springer
    Experimental mechanics 25 (1985), S. 344-353 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The mixed-mode, elastodynamic state of stress in the neighborhood of a constant-velocity crack tip is used to generate numerically unsymmetric isochromatics. Unsymmetry associated with the third-order terms of a mixed-mode stress field, with and without the Mode II singular stress term, is also investigated. In extractingK I from an unsymmetric isochromatic pattern, errors in the Mode I fracture parameters due to the assumed presence ofK II in aK I stress field were found to be significant when data are taken more than 4 mm from the crack tip.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02321332
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    DeterminingK and related stress-field parameters from displacement fields (1985)
    Springer
    Experimental mechanics 25 (1985), S. 399-407 
    Details
    ISSN: 1741-2765
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A general algorithm is presented that computes the stress-field parameters for opening-mode crack problems in a least-squares sense from full-field moiré or speckle-displacement fringe patterns. The algorithm can be used in the presence of rigid-body rotation and does not require absolute fringe numbering. Extensive numerical experiments were conducted with the algorithm to determine the sensitivity of the method to experimental errors. Small random position errors in locating the fringe maxima were found to have a negligible influence on the stress-intensity-factor calculation when the number of data points was about ten times greater than the number of unknown stress-field parameters. It was also found that systematic position errors due to an incorrectly specified crack-tip location could be minimized by assuming various crack-tip locations in the vicinity of the actual crack tip and selecting the best fit results. Bothu andv fields were found to be equally suitable for determination of the stress-intensity factor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02321339
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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