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  • 1985-1989  (3)
  • 1985  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Measurement ofN τ-methylhistamine concentrations in plasma and urine as a parameter for histamine release during anaphylactoid reactions (1985)
    Springer
    Inflammation research 16 (1985), S. 76-79 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract N τ-methylhistamine concentrations in plasma and urine were determined using a newly developed simultaneous determination for histamine andN τ-methylhistamine, based on isotope dilution mass fragmentography. Three groups of patients were investigated: patients receiving intravenously-administered iodamide for excretory urography, patients receiving a wasp-sting challenge, and patients treated with an intravenously-administered muscle relaxant. In all patients showing a distinct systemic anaphylactic or anaphylactoid reaction histamine andN τ-methylhistamine concentrations were found to be elevated. From the results of this study it can be concluded thatN τ-methylhistamine in plasma and urine is a good parameter for histamine release, and that the determination of this histamine metabolite are less hampered by possible artefacts (due to basophil disrupture, a very short half-life time or bacterial production) than determinations of histamine itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983105
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Histamine in late asthmatic reactions following house-dust mite inhalation (1985)
    Springer
    Inflammation research 16 (1985), S. 252-255 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to investigate the role of histamine in the late asthmatic reaction (LAR) following house-dust mite (HDM) inhalation, we studied, with hourly intervals, urinaryN τ-methylhistamine (an important metabolite of histamine) in 14 allergic asthmatic patients before and after broncho provocation with HDM. Four patients showed an early asthmatic reaction (EAR), while 10 patients developed a LAR as well. In the hour following the EAR a significant increase in urinaryN τ-methylhistamine was observed as compared to the control day (0.01〈p〈0.05). During the LAR no increase of this metabolite was detected in the urine of the patients. Additionally, histamine was measured in broncho alveolar lavage fluid (BAF) obtained from 6 patients during the HDM-provoked LAR and compared to histamine levels in BAF from patients without a LAR, following broncho provocation. In the LAR group higher histamine levels were found than in the other patient and control groups. For the whole patient group no correlation was found between the degree of bronchial obstruction during the LAR and the BAF histamine values. No difference was found inN τ-methylhistamine in BAF between patients with LAR and controls. Thus histamine metabolite studies in the urine failed to provide evidence of involvement of histamine in the LAR, while further data are needed to interpret the results of local sampling in the lung.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01983153
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Effect of oral slow-release terbutaline on early morning dyspnoea (1985)
    Springer
    European journal of clinical pharmacology 28 (1985), S. 159-162 
    Details
    ISSN: 1432-1041
    Keywords: terbutaline ; asthma ; slow-release formulation ; early morning dyspnoea ; side-effects ; serum terbutaline level
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight male patients with partly reversible airflow obstruction, who had a diurnal variation in peak expiratory flow rate (PEFR) of more than 20% were treated with placebo and slow-release terbutaline tablets (5 mg at 08.00 hours and 10 mg at 20.00 hours) for 8 days. On Day 8 of each period, PEFR and serum terbutaline were measured at 4 and 2-h intervals, respectively. PEFR on the terbutaline day showed a significant increase at 08.00, 12.00, 24.00, 04.00 and 08.00 hours as compared to the placebo day. Slow-release terbutaline prevented early morning dyspnoea. The serum concentration was 3.3 ng/ml during the day and 3.5 ng/ml during the night. During terbutaline therapy the patients reported fewer complaints than during the placebo period. It was concluded that slow-release terbutaline tablets are suitable for twice daily treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00609685
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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