ISSN:
0935-6304
Keywords:
Supercritical fluid chromatography, SFC
;
Fused silica packed column
;
Pressure programming
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A versatile system with a slurry-packed capillary column was developed for supercritical fluid chromatography, which is capable of programming both inlet and outlet pressure independently, as well as using a restrictor to apply back pressure. This system revealed the relationships between pressure drop, flow rate, and linear velocity in pressure-programmed supercritical fluid chromatography. In the restrictor system, both the pressure drop and the flow rate increased almost linearly with inlet pressure, while under conditions of constant pressure drop characteristic behavior was observed which depended on the density-viscosity relationships of supercritical fluid. Resolution in the separation of polysiloxane oligomers was found to be increased by increasing the ratio of pressure drop to pressure-programming rate, although the sensitivity decreased due to the increase in peak volume. The system controlling both inlet and outlet pressure has distinct advantages over the restrictor system controlling both inlet and outlet pressure has distinct advantages over the restrictor system in practical in practical operations.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jhrc.1240091107
Permalink
