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ACCELERATED PROGRESSION OF DIABETIC NEPHROPATHY IN THE SPONTANEOUSLY HYPERTENSIVE STREPTOZOTOCIN DIABETIC RAT (1986)

Cooper, M. E. ; Allen, T. J. ; Jerums, G. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Clinical and experimental pharmacology and physiology 13 (1986), S. 0

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ISSN: 1440-1681

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: 1. Streptozotocin (STZ)-diabetes was induced in spontaneously hypertensive (SHR) and Wistar Kyoto (WKY) rats with their litter mates serving as controls. The animals were studied for 6 months and blood pressure, weight, urinary and serum glucose, creatinine clearance, total proteinuria and albuminuria were measured monthly.2. With induction of diabetes, there was a significant rise in creatinine clearance in the hypertensive diabetic animals (SHR-STZ). SHR-STZ (n= 6) developed higher levels of total proteinuria than WKY-STZ (n= 5) although the rise from basal levels was only apparent after 20 weeks of diabetes. All SHR-STZ developed albustix positive proteinuria after 6 months of diabetes.3. In the first 12 weeks after onset of diabetes, albuminuria increased to a greater degree in SHR-STZ than in WKY-STZ. This occurred before there was a detectable rise in total proteinuria.4. The SHR-STZ model of genetic hypertension and diabetes may be suitable for the evaluation of antihypertensive therapy in human diabetic renal disease.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1440-1681.1986.tb02394.x

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Regional distribution of glucose utilization in the telencephalon of toads in response to configurational visual stimuli: a14C-2DG study (1986)

Finkenstädt, T. ; Adler, N. T. ; Allen, T. O. ; [et al.]

Springer

Journal of comparative physiology 158 (1986), S. 457-467

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ISSN: 1432-1351

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary The regional glucose utilization in the telencephalon of toadsBufo bufo during stimulation with different visual key stimuli was quantitatively mapped by means of the14C-2DG autoradiographic method: (i) a 4×28 mm2 worm-like stripe (W) eliciting prey catching responses, (ii) a 84×84 mm2 square (S) releasing predator avoidance responses, and (iii) a 28×4 mm2 antiwormlike stripe (A) eliciting no motor response. Various telencephalic structures changed14C- 2DG uptake statistical significantly during stimulation with the above visual objects in comparison with binocular enucleated animals (brain-to-brain comparison) and in comparison between both hemispheres in monocular animals (interhemispherical comparison): (1) The ventral two-thirds of the posterior half of the medial palliumdecreased 14C-2DG uptake during W- and S-experiments, particularly in response to W. (2) In the posterior two-thirds of the lateral pallium,14C- 2DG uptake wasdecreased in response to the worm-, andincreased in response to the square (S) and antiworm stimuli (A). (3) The ventral striatumincreased uptake of14C-2DG during the animal's response to W- and S-stimuli significantly stronger than in the A-experiment. (4) The dorsal striatum also showed a significant change in14C-2DG uptake which, on a lower level, was not correlated with the type of stimulation experiment. Various prosencephalic structures are involved in circuitries related to attentional phenomena and the gating of prey catching and predator avoidance behavior. The different functions of these structures are discussed.