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  • 1985-1989  (7)
  • 1989  (3)
  • 1987  (4)
  • 1
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 65 (1989), S. 4068-4070 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The possibility of relaxation oscillations in the laser output of a discharge-pumped copper (CuCl) vapor laser is explained qualitatively considering resonance-radiation trapping and collisional effects for experimental results.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 58 (1987), S. 1852-1855 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We have developed a low-cost rapid-scanning autocorrelator which enables us to monitor picosecond optical pulses up to almost 100 ps. To achieve wide-scan range, each arm of a Michelson-type interferometer is scanned 180° out of phase by using audio speakers, and also only one-half of a full autocorrelation waveform of the pulses is observed. The present apparatus is usefully used to measure about 80-ps pulses generated from a cw mode-locked Nd:YAG laser.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 16 (1989), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The possible interactions between the renal effects of atrial natriuretic peptide (ANP) and angiotensin II (All) were studied in normal sodium-replete human subjects. Recent investigations have suggested that ANP inhibits the pressor and volume-retaining effects of activation of the renin-angiotensin system. Thus, ANP may attenuate the effects of All on renal haemodynamics or tubular transport.2. ANP (0.1 μg/kg per min, 60 min) was intravenously infused into eight normal human subjects with and without pretreatment with enalapril (20 mg, per oral), an inhibitor of the converting enzyme, and during infusion of All (10 mg/kg per min).3. ANP infusion alone caused increases in the urine volume (from 96 ± 23 to 229 ± 44 mL/h, P 〈 0.05) and urinary sodium excretion (from 11.5 ± 1.6 to 20.9 ± 4.2 mEq/h, P 〈 0.05). These changes were accompanied by an increase in the glomerular filtration rate (from 127 ± 9 to 158 ± 9 mL/min, P 〈 0.05). ANP infusion after enalapril administration lowered the mean blood pressure (from 76 ± 2 to 71 ± 3 mmHg, P 〈 0.05) to a level similar to that observed during ANP infusion alone (from 84 ± 2 to 74 ± 2 mmHg, P 〈 0.01), but did not result in a significant diuresis (from 139 ± 23 to 174 ± 51 mL/h) or natriuresis (from 19.7 ± 2.5 to 14.3 ± 3.4 mEq/h, P 〈 0.05). This combined treatment with a converting enzyme inhibitor and ANP reduced both the glomerular filtration rate (160 ± 9 to 141 ± 10 mL/min) and the renal plasma flow (from 775 ± 49 to 570 ± 45 mL/min, P 〈 0.01).4. The antinatriuretic effects of exogenous All were reversed by superimposed ANP infusion (urinary sodium excretion: from 4.8 ± 1.0 to 24.3 ± 5.2 mEq/h, P 〈 0.01). Under these conditions, the glomerular filtration rate increased (from 114 ± 6 to 156 ± 7 mL/min, P 〈 0.05) to levels similar to those observed with ANP infusion alone. In addition the increased tubular sodium reabsorption induced by All was inhibited by concomitant ANP infusion (fractional proximal tubular sodium reabsorption: from 90.7 ± 3.5 to 80.3 ± 16.6%, P 〈 0.05, fractional post-proximal tubular sodium reabsorption: from 91.5 ± 9.8 to 87.6 ± 8.8%, P 〈 0.05).5. These results suggest that ANP interacts with endogenous All particularly in the glomerulus, to cause a diuresis and natriuresis, and also suggest that ANP inhibits All-induced tubular sodium reabsorption.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirty-one patients with previously untreated advanced non-small cell lung cancer were treated with mitomycin C (10 mg/m2, day 1), vinblastine (5 mg/m2, days 1 and 15), and cisplatin (80 mg/m2, day 1). Combination chemotherapy was repeated at 4-week intervals until disease progression or unacceptable toxicity. The overall response rate was 52.0%, with a median survival time of 8 months. The median duration of response was 16 weeks (range, 7–49 weeks), and 23% of the patients survived for more than 1 year. Toxicity included moderate myelosuppression, mild nephropathy, and severe nausea and vomiting. This combination therapy of anticancer agents appears to have antitumor activity, but not to have satisfactory therapeutic activity for advanced non-small cell lung cancer.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    The journal of membrane biology 100 (1987), S. 13-19 
    ISSN: 1432-1424
    Keywords: smooth muscle cells ; Ca channel ; whole cell recording ; inactivation ; Ca dependency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Ca-channel currents were recorded in Cs-loaded single smooth muscle cells from rat vas deferens to define the dependence of the inactivation time course on Ca concentration. The decay of Ca-channel current obtained in a Ba2+- or Sr2+-containing external solution during long voltage-clamp pulses was much slower than that in a Ca-containing solution. The difference was not due to a change in the surface potential of the membrane as judged from the steady-state activation and inactivation curves. When Ca was the charge carrier, increasing external Ca concentration slightly accelerated the rate of inactivation. In addition, the rate of inactivation of Ca-channel current in 10.8mm Ba was also accelerated by adding Ca to the external solution in a concentration-dependent manner. The time course of Ca-current inactivation was slowed when the cells were dialyzed with a high concentration of citrate, a Ca-chelating agent. From these results, we concluded that a mechanism regulated by intracellular Ca activity plays a role in the inactivation of Ca channels in smooth muscle. The Ca-dependent process may protect against Ca overload by regulating Ca entry in smooth muscle cells.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 190 (1989), S. 2693-2701 
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Chemically and thermally stable thin films of polyphthalocyanine were prepared by a simple evaporation-polymerization method. The rectifying characteristics of metal/semiconductor/metal (MSM) type sandwich devices with the film were studied. A Schottky type device metal (Cu, Al, Ti)/polyphthalocyanine/Cu shows reproducible rectifying characteristics when Ti is selected as a counter electrode. The reproducibility is improved by pre-oxidation treatment of the surface of Cu substrate. Best electric parameters for the device are as follows: rectifying ratio = 14; threshold potential difference = 0,61 V; saturation current = 2,5 · 10-6 A · cm-2; barrier height = 0,75 eV; diode ideality parameter = 4,23. Doping of five kinds of quinones [p-benzoquinone (p-BQ), tetrabromo-p-benzoquinone (p-TBBQ) tetrachloro-p-benzoquinone (p-TCBQ) tetrachloro-o-benzoquinone (o-TCBQ) 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ)] and 2,5-cyclohexadien-1,4-diylidenedimalodinitrile (TNCR) in thin films of polyphthalocyanine affected electrocharacteristics in some cases. The diode ideality parameter decreases to 2,17 at 0,90 · 10-6 mol · cm-1 of p-TBBQ, and the rectifying ratio increases to about fourteen times by doping p-TBBQ and p-TCBQ. The doped device shows a rectifying response up to 1 kHz.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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