ISSN:
1573-6903
Keywords:
ATP-sulfurylase
;
APS-kinase
;
liver
;
brain
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Chromatography of brain and liver 100,000g supernatants over HPLC molecular sieve columns revealed striking differences in the molecular weight distribution of ATP-sulfurylase and APS-kinase of the two tissues, pointing to different enzymic species for both enzymes in brain and liver. This was further substantiated by kinetic characterization of the two enzymes of both tissues. APS-kinase of liver is allosterically activated by ATP, while the brain enzyme is not. ATP-sulfurylase of brain is activated at high, but still physiological concentrations of ATP. Brain ATP-sulfurylase is inhibited by phenylalanine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00993243
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