ISSN:
1574-4647
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract The spontaneous motility and chemotaxis of PMNs have been investigated in 25 healthy subjects aged 69–88 years (79.04 ± 4.6) and compared with the values obtained in 25 subjects aged 17–35 years (25.6 ± 5.9). For spontaneous motility, the values were 32 ± 9 in the young subjects, in comparison with 24 ± 11 in the elderly (p 〈 0.05). For chemotaxis the values were 34 ± 14 in the young subjects and 25 ± 10 in the elderly (p 〈 0.02). A group of 8 elderly subjects received 2 g ascorbic acid daily for 1 month. Measurements of spontaneous motility and chemotaxis were conducted, and the results were compared with those obtained prior to the treatment. Neither parameter was significantly modified. Another group of 8 elderly subjects received 50 mg of levamisole daily for 3 days. This drug caused a significant increase in spontaneous motility (p 〈 0.0001) and chemotaxis (p 〈 0.05). In our experience, the elderly exhibit a decrease in spontaneous motility and chemotaxis of PMNs in comparison with those values obtained in young people. Although levamisole increased the values of both parameters, ascorbic acid did not.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02431745
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