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  • 1985-1989  (2)
  • 1988  (2)
  • 2,3-Dimercaptosuccinic acid  (1)
  • Finite-element method  (1)
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Years
  • 1985-1989  (2)
Year
  • 1988  (2)
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Influence of thiamine and ascorbic acid supplementation on the antidotal efficacy of thiol chelators in experimental lead intoxication (1988)
    Springer
    Archives of toxicology 62 (1988), S. 301-304 
    Details
    ISSN: 1432-0738
    Keywords: Lead ; Thiamine ; Ascorbic acid ; Chelation ; α-Mercapto-β-(2-furyl) acrylic acid ; 2,3-Dimercaptosuccinic acid ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of the administration of thiamin (vitamin B1), ascorbic acid (vitamin C) or their combination on the efficacy of two thiol metal chelators, viz. α-mercapto-β-(2-furyl) acrylic acid (MFA) and 2,3-dimercaptosuccinic acid (DMS), in counteracting lead (Pb) toxicity was investigated in rats. Ascorbic acid or its combination with thiamine enhanced the urinary elimination of Pb, reduced the hepatic and renal burden of Pb, and reversed the Pb-induced inhibition of the activity of blood 5-aminolevulinic acid dehydratase (δ-ALA-D). All these effects were more evident in DMS- than in MFA-treated rats. The combination of MFA and DMS treatments further improved the performance of the animals in enhancing urinary Pb excretion and in reducing Pb hepatic levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00332491
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Potential distribution in the thorax in relation to electrical field plethysmography (1988)
    Springer
    Medical & biological engineering & computing 26 (1988), S. 303-309 
    Details
    ISSN: 1741-0444
    Keywords: Field distribution ; Finite-element method ; Plethysmography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract A two-dimensional model of the thorax has been analysed to study the electrical potential distributions under various physiological conditions in relation to electrical field plethysmography. The quasi-harmonic equation has been solved over a cross-section of the thorax with the help of a finite-element method under the assumptions of homogeneous and isotropic tissue characteristics. Potentials along the boundary of the model have been plotted and the optimum electrode locations derived from the analysis corresponded well with the experimentally obtained positions. It is concluded that cardiac activity can be monitored effectively in the presence of lung activity. It has also been found that, with a suitable modification of the positions of the pick-up electrodes, lung activity can also be monitored. The equipotential lines drawn and the current densities computed have provided a picture of the field distribution pattern in the thoracic model. The analysis showed that the technique fulfils the preliminary requirements of a plethysmographic tool.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02447085
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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