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Digitale Medien

Atracurium recovery: prediction of safe reversal times with edrophonium (1989)

CASHMAN, J. N. ; JONES, R. M. ; ADAMS, A. P.

Oxford, UK : Blackwell Publishing Ltd

Anaesthesia 44 (1989), S. 0

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ISSN: 1365-2044

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: The time to safe return of neuromuscular function after atracurium 0.3 mg/kg intravenously was assessed in 24 patients in whom anaesthesia was maintained with halothane 0.5%. Safe reversal (recovery to a T4 ratio 〉 05), after this dose of atracurium, could only be reliably and rapidly (〈 2 minutes) achieved with edrophonium if a period greater than 30 minutes elapsed since administration of the relaxant. This coincides with the appearance of four recognisable twitches if a train-of-four pattern of nerve stimulation is used. Thus, if no monitoring equipment is available, at least half-an-hour should elapse after administration of atracurium in a moderate dose (e.g. 0.3 mg/kg) before rapid and reliable reversal can be anticipated. Four twitches in a train-of-four should be recognisable, if a nerve stimulator is available.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1365-2044.1989.tb09095.x

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