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Sideways Killing: The Cytolysis of Fc Receptor-Bearing Cells through Bridging to Cytolytic T Lymphocytes by Antibodies Specific for the T-Cell Receptor-T3 Complex (1989)

ITO, M. ; USUBA, O. ; UNKELESS, J. C. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Scandinavian journal of immunology 29 (1989), S. 0

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ISSN: 1365-3083

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Cytolylic T lymphocytes (CTL) cause cytolysis of foreign or virus-infected syngeneic cells when recognition of the target plus major histocompatibility complex (MHC) occurs via the T-cell receptor (TCR). The recognition event leads to intimate contact between the two cells and activation of the cytolytic effector. Activation and target cell lysis can also occur in the presence of antibodies to the TCR. This is accomplished by bridging the effector cell TCR to the target cell FcR by an anti-TCR monoclonal antibody (MoAb). Recent findings have placed the role of the FcR in this event in a questionable light. We confirm the importance of FcγR by demonstrating that: (a) melanoma cells are killed by CTL clones in the presence of anti-TCR CD3 antibodies only when the melanoma cells express the FcγR on their surface; (b) native Ig, heat-aggregated Ig, or an Fc fragment from an antibody expressing the same isotype as the anti-TCR antibody can block the killing of high avidity FcγRI-bearing cells mediated by anti-TCR antibody (F23.1); and (c) anti-FcγR MoAb (2.4G2)and a truncated soluble FcγRII molecule inhibit the killing of low-avidity FcγRII-bearing cells mediated by anti-CD3 MoAb (145–2C11). Thus, we show that both high-avidity FcγRI and low-avidity FcγRII can mediate sideways killing depending upon the isotype of the anti-TCR antibody and the type of FcR present on the target cell surface.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-3083.1989.tb01170.x

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The effects of emitter heating on field ionization mass spectra of nitrogen-containing organic molecules (1989)

Nelson, P. R. ; Abbey, L. E. ; Moran, T. F.

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 24 (1989), S. 22-26

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ISSN: 0030-493X

Keywords: Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Field ionization mass spectra of nitrogen-containing organic compounds were examined as a function of carbon dendrite emitter heating current. The intensities of singly charged molecular, quasimolecular and dimer ions decreased with increasing emitter heating current; whereas, the opposite trend was observed for singly charged fragment ions. The abundance of doubly charged ions originating from aromatic compounds increased with heating current.

Additional Material: 9 Ill.