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  • 1985-1989  (3)
  • 1960-1964
  • 1989  (3)
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  • 1985-1989  (3)
  • 1960-1964
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  • 1
    Electronic Resource
    Electronic Resource
    Hippocampal Membranes Contain a Neurotrophic Activity That Stimulates Cholinergic Properties of Fetal Rat Septal Neurons Cultured Under Serum-Free Conditions (1989)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 52 (1989), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Primary cultures of fetal rat septal neurons were used to identify a membrane-associated cholinergic neurotrophic activity. Under serum-free culture conditions, ∼98% of the septal cells are neurons, and ∼6% of the neurons are cholinergic as determined immunocytochemically. Crude membranes prepared from rat hippocampal homogenates stimulate choline acetyltransferase (ChAT) activity in treated septal neurons. The membrane-associated trophic activity is apparent at lower protein concentrations than activity present in the soluble fraction and is unevenly distributed in various brain regions; it is highest in hippocampus and striatum and negligible in cerebellum. Membrane trophic activity is developmentally regulated, is heat and trypsin sensitive, and increases the rate of expression of ChAT in septal neurons. Upon gel nitration chromatography of a high-salt membrane extract, trophic activity elutes as a broad peak in the 500 kilodalton (kD) molecular mass range. Stimulation of septal neuronal ChAT activity by either crude membranes or partially purified preparations is not inhibited by antibodies against nerve growth factor (NGF), and its maximal activity is additive to maximally active doses of NGF. The results indicate that hippocampal membranes contain cholinergic neurotrophic activity which may be important for the development of septal cholinergic neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1989.tb02547.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Substance P, like acetylcholine, augments one type of Ca2+ current in isolated smooth muscle cells (1989)
    Springer
    Pflügers Archiv 413 (1989), S. 565-567 
    Details
    ISSN: 1432-2013
    Keywords: Neuropeptide ; Muscarinic receptor ; Voltage Clamp ; Calcium Channels ; Patch Clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Electrophysiological recordings from freshly-dissociated smooth muscle cells from toad stomach revealed that substance P enhances one of two types of Ca2+ currents. That is, substance P enhances the slowly inactivating, high-threshold current but not the fast inactivating, low-threshold current. Acetylcholine has the same effect, but the acetylcholine action is blocked by atropine whereas the substance P action is not, indicating that the two agents act at different receptor sites. Thus substance P, like acetylcholine, has a dual excitatory action on the smooth muscle cells employed in these studies, enhancing a specific type of Ca2+ current, as demonstrated here, and suppressing a voltage-sensitive K+ conductance as previously described [Sims, S.M., Walsh, J.V., Jr. & Singer, J.J. (1986) Am. J. Physiol.251, C580–C587].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00594191
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Images of crystalline alkanes obtained with scanning tunneling microscopy (1989)
    Springer
    The European physical journal 76 (1989), S. 99-105 
    Details
    ISSN: 1434-6036
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Uncoated layered alkane (paraffin) objects with a thickness of up to a hundred nanometers have been imaged by scanning tunneling microscopy. This is surprising in view of the generally assumed excellent insulating nature of paraffins. Tilted layers were observed for n-alkanes of various chain lengths. The chemical nature of the imaged objects was demonstrated by the changes of structure observed near the respective melting temperature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01323491
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    Paper (German National Licenses)
    Fulltext
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