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  • 1990-1994  (3)
  • 1993  (2)
  • 1990  (1)
  • Engineering  (2)
  • AT1 receptor  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 347 (1993), S. 658-663 
    ISSN: 1432-1912
    Keywords: Angiotensin II ; Myocardial contraction ; Pithed rat ; AT1 receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The cardiovascular effects of angiotensin II were examined in aortic blood pressure-controlled and-uncontrolled pithed rats. Angiotensin II induced a dose-dependent increase in diastolic blood pressure, left ventricular pressure (LVP), dP/dt (the first derivative of LVP) and heart rate in pithed rats. The maximal responses for these parameters were similar to those to noradrenaline, except for the rise in diastolic blood pressure, where noradrenaline caused a greater increase than angiotensin II. After treatment with propranolol, the positive chronotropic effect of angiotensin II was abolished. Angiotensin II produced a dose-dependent increase in diastolic blood pressure, which was similar to that of vasopressin, and an increase in dP/dtmax, which proved much greater than that of vasopressin. When aortic blood pressure was controlled and the β-receptors were blocked by propranolol, angiotensin II caused a dose-dependent increase in dP/dtmax without affecting the left ventricular enddiastolic pressure. The same results were obtained after both β- and α-adrenoceptors were blocked by propranolol and phentolamine. Losartan but not PD 123177 caused parallel rightward shifts of the dose-response curve of angiotensin II for dP/dtmax in the aortic blood pressure controlled pithed rat without altering the maximal response. It is concluded that in the pithed rat angiotensin II produced an increase in myocardial contractile force which is not mediated by β- or α-adrenoceptors. The inotropic effect appears to be mediated by angiotensin receptors, of the AT1-subtype.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Communications in Applied Numerical Methods 6 (1990), S. 215-222 
    ISSN: 0748-8025
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: In this study, the advantage of the multi-variable finite-element model based on the generalized virtual work principle is described. The model has been applied to the elasto-plastic fracture analysis with finite deformations. Using the multi-variable finite-element model with a‘breakable finite-element’ concept, the authors proposed an algorithm which can more accurately simulate the crack growth. Numerical examples illustrate that the algorithm presented can be successfully used to predict whether the crack growth is stable or unstable. The rupture effective strain is considered as a fracture criterion, and some comparisons between various criteria are also provided.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 16 (1993), S. 65-81 
    ISSN: 0271-2091
    Keywords: Probabilistic numerical method ; Neumann expansion method ; Fluid flow ; Solid-liquid two-phase flow ; Stochastic process ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Solid-particle motion and related transport phenomena in two-phase flow are fluctuating processes in space and time. A deterministic method can describe only partially the intrinsic physics of these processes. In this paper, the fluctuations of the flow parameters are modelled by considering the spatial correlations, and a probabilistic computational method for two-phase flow is presented. The probabilistic governing equations have been discretized in space using a finite volume method, and then solved by applying the Neumann expansion method. This last method is time efficient, and its convergence can be guaranteed even for large fluctuations. A liquid-solid particle mixture flow in a circular pipe is taken as an example. Computational results illustrate the merit of the probabilistic approach for the prediction of two-phase flow phenomena.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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