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Behavioral effects of MK-801 in the rat (1990)

Wozniak, D. F. ; Olney, J. W. ; Kettinger, L. ; [et al.]

Springer

Psychopharmacology 101 (1990), S. 47-56

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ISSN: 1432-2072

Keywords: MK-801 [(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate] ; N-methyl-d-aspartate receptor antagonists ; Learning and memory ; Sensorimotor function

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract Several experiments were conducted to study the effects of the noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801, on learning and memory in the rat. Rats displayed impaired performance on several sensorimotor tests and appeared grossly intoxicated when treated IP with 0.2 mg/kg MK-801, but not when treated with lower doses (0.05 or 0.1 mg/kg). Postacquisition performance on two spatial learning tasks involving working memory protocols (reinforced alternation and radial arm maze) was impaired by MK-801 at intoxicating doses (≥0.2 mg/kg) but not at lower doses (0.05 or 0.1 mg/kg). Using a position habit reversal task, we found that rats could learn to reverse a position habit while under the influence of a nonintoxicating dose of MK-801 (0.1 mg/kg), but when tested on the following day performed as if they did not recall what they had learned. Thus, acute administration of a nonintoxicating dose of MK-801 disrupts the retention of new information learned under the influence of the drug but does not interfere with the performance of tasks that are well learned before the drug is administered. Whether the performance deficits on the spatial learning tasks observed only following intoxicating doses of MK-801 reflect an effect on memory is not clear.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02253717

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Fundamental modeling in anionic polymerization processes (1990)

Chang, C. C. ; Miller, J. W. ; Schorr, G. R.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 39 (1990), S. 2395-2417

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ISSN: 0021-8995

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The anionic solution polymerization of butadiene was studied employing both batch and continuous reactor operations with n-butyllithium (n-BuLi) initiator, tetramethylethylenediamine (TMEDA) modifier, and hexane solvent. A model was proposed that described the kinetics as a function of both the fully modified and unmodified regressed rate data. Using the proposed kinetic model, the conversion, vinyl structure, and heterogeneity index of polymers produced for a series of continuous runs were successfully predicted. The model was used to simulate several process configurations.

Additional Material: 10 Ill.