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A transforming Kirsten ras oncogene in an oral squamous carcinoma (1990)

Howell, R. E. ; Wong, F. S. H. ; Fenwick, R. G.

Oxford, UK : Blackwell Publishing Ltd

Journal of oral pathology & medicine 19 (1990), S. 0

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ISSN: 1600-0714

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: This investigation has employed the NIH 3T3 cell transfection assay in an effort to detect transforming genes in DNA from squamous carcinomas of the head and neck. Of 11 tumor DNAs tested, 1 DNA sample from a gingival squamous carcinoma was able to produce primary and secondary transformants containing the human K-ras oncogene. This is the first report of an activated ras oncogene derived from a carcinoma of the head and neck. Head and neck cancers may possess activated ras oncogenes more often than is indicated by this study because of the relative inefficiency of transfection assays in detecting large transforming genes such as K-ras.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1600-0714.1990.tb00849.x

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Complement C4 and heat shock protein 70 (HSP70) genotypes and type I diabetes mellitus (1990)

Caplen, Natasha J. ; Patel, Ashok ; Millward, Ann ; [et al.]

Springer

Immunogenetics 32 (1990), S. 427-430

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ISSN: 1432-1211

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Type I diabetes is strongly associated with the major histocompatibility complex (MHC) class II region (DR and DQ loci), and to a lesser extent the class III region (complement C4 loci). Restriction fragment length polymorphism analysis was employed to investigate the C4 and heat shock protein 70 (HSP70) loci of 176 patients with type I diabetes and 92 healthy controls. In the patient population there was an excess of deletions of the C4A locus (48.5% vs 22.1%, P 〈 0.0005). The HSP70 probe in conjunction with the restriction endonuclease Pst I detects two alleles of 9 or 8.5 kilobases (kb). The 8.5 kb allele was significantly increased in the patient group compared to healthy controls (0.569 vs 0.353, respectively, P 〈 0.0005). Furthermore, a C4A deletion nearly always occurred with the 8.5 kb HSP70 allele, suggesting that it may be a marker of the HLA-A1, B8, C4A deletion, DR3 extended haplotype.