ISSN:
1432-1041
Keywords:
atrial natriuretic peptide
;
dopamine
;
renal response
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The role of dopamine synthesis in the renal actions of human α-atrial natriuretic peptide (αANP) was investigated in six dehydrated volunteers using the DOPA decarboxylase inhibitor carbidopa. Each subject received oral placebo or carbidopa (100 mg) followed by an infusion of αANP 10 pmol · kg−1 · min−1 for 1 h. The responses to placebo alone and to carbidopa alone were investigated on separate occasions. αANP produced a similar increase in plasma immunoreactive αANP whether placebo or carbidopa pretreatment had been given. Urinary dopamine excretion was increased by αANP. Carbidopa pretreatment substantially attenuated this increase without affecting the natriuretic or water-diuretic response to αANP. Carbidopa also failed to alter the change in filtration fraction produced by αANP. The results suggest that increased synthesis of intrarenal dopamine is not required for the renal effects of αANP in man.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315020
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