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Combination of interferons and cytostatic drugs for treatment of advanced colorectal cancer (1991)

Klein, H. O. ; Golbach, G. ; Voigt, P. ; [et al.]

Springer

Journal of cancer research and clinical oncology 117 (1991), S. S214

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ISSN: 1432-1335

Keywords: Immuno-chemotherapy ; Interferonβ ; Interferonγ ; Metastatic colorectal cancer ; Ifosfamide ; Mafosfamide ; 5-Fluorouracil ; Mitomycin C ; Carboplatin ; Bleomycin

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Three phase I/II trials were performed in patients with metastatic colorectal cancer using immunochemotherapy — a combination of recombinant interferonβ undγ with low doses of cytostatic drugs. The third regimen, consisting of a cytostatic component containing 5-fluorouracil plus carboplatin plus mitomycin C besides the interferons, produced a high remission rate of 47%: 14/30 patients responded. The tolerability of this protocol was good and it could be administered on an out-patient basis.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01613230

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Acute treatment with vitamin E does not protect the regionally ischemic, reperfused porcine heart (1991)

Klein, H. H. ; Pich, S. ; Nebendahl, K. ; [et al.]

Springer

Basic research in cardiology 86 (1991), S. 32-39

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ISSN: 1435-1803

Keywords: ischemia ; reperfusion ; vitamin E ; infarct size ; regionalsystolic shortening

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Thirty pigs were randomly assigned to a blind treatment with vitamin E or placebo. Ten animals each received 0.5g d-alpha tocopherol intravenously before ischemia (group 1) or before reperfusion (group 2). Ten control pigs were treated with a lipid emulsion as placebo. The left anterior descending coronary artery was distally ligated for 45 min followed by 3 days of reperfusion. Infarct size was determined as ratio of infarcted (tetrazolium stain) to ischemic myocardium (dye technique). Regional systolic shortening was assessed by sonomicrometry. Myocardial and plasma concentrations of vitamin E were determined by high-performance liquid chromatography. Global hemodynamic parameters and estimated left ventricular oxygen consumption did not differ among the three groups. Intravenous treatment with vitamin E raised the plasma levels of this vitamin from 1 ± 0.3 mg/l (control group) to 21 ± 6 mg/l before ischemia, to 4 ± 2 mg/l before reperfusion and to 2 ± 0.6 mg/l at the end of the experiments in group 1. In group 2, vitamin E plasma levels increased from 1 ± 0.3 mg/l to 24 ± 13 mg/l before reperfusion and to 2 ± 0.6 mg/l after 3 days of reperfusion. At the end of the experiments, myocardial vitamin E concentrations amounted to 4.2 ± 0.7 ng/mg fresh weight (control group), 9.7 ± 2.1 ng/mg (group 1), and to 8.7 ± 1.4 ng/mg (group 2). The increase in vitamin E plasma concentration was not associated with a cardioprotective effect. Infarct sizes of the three groups (group 1: 68 ± 12%, group 2: 66 ± 15%, control group: 69 ± 8%) were almost identical. Furthermore, recovery of systolic shortening was not improved by the acute vitamin E treatment. Mean systolic shortening of the reperfused segment amounted to 4% in the two treatment groups and 3% in the control group after 3 days of reperfusion. These results suggest that an acute increase in vitamin E plasma concentration before ischemia or during the early phase of reperfusion does not protect the ischemic, reperfused porcine heart.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02193869

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Substituierte Alkinyle als axiale Liganden an häminähnlich gebundenem Eisen(III) - Einordnung in eine spektrochemische SerieHerrn Professor Dr. E. Hoyer zum 60. Geburtstag gewidmet (1991)

Jäger, E.-G. ; Hähnel, H. ; Klein, H.-F. ; [et al.]

New York, NY : Wiley-Blackwell

Journal für Praktische Chemie/Chemiker-Zeitung 333 (1991), S. 423-430

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ISSN: 0021-8383

Keywords: Chemistry ; Organic Chemistry

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: Substituted Alkinyles as Axial Ligands at Hemine Like Bound Iron(III) - Incorporation into a Spectrochemical Series.Substituted lithium alkynyles Li—C≡C—R (R = tBu, Ph, p-Cl—C6H4, Me3Si, iPr3Si, Ph3Si) react with the hemine like macrocyclic iron(III) complex 6,13-di(ethoxycarbonyl)-5, 14-dimethyl-1, 4, 8, 11-tetraazatetradeca-4,6,12,14-tetraenato[2-]iron(III)-iodide (formula 2;) in tetrahydrofuran to form anionic low-spin di-adducts [fe(C≡C—R)2]-. The incorporation of the alkynyles into a spectrochemical series of the axial ligands (studied by the sharp equatorial-ligand-to-metal CT absorption band) results in the wavelength-sequence (nm): OH- (≍ 510) « N3- (≍ 625) 〈 tBu—C≡C- (664) 〈 NH3 (666) 〈 Ph—C≡C- (692) 〈 Ph—NH2 (695) 〈 Me3Si—C≡C- (698) 〈 SCN- (713) 〈 Ph3Si—C ≡ C- (716) 〈 CN- (739) 〈 4-picoline (759) 〈 pyridine (765) 〈 nicotinamide (776) 〈 methylnicotinat (788) 〈 pyrazine (798) and points to a significant π-acceptor ability of the silyl substituents.

Additional Material: 2 Tab.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/prac.19913330307

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