ISSN:
1432-2307
Keywords:
Experimental colonic adenocarcinoma
;
Transplantation
;
Metastases
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Transplantable tumour lines were obtained from one duodenal carcinoma induced byN-methyl-N′-nitro-N-nitrosoguanidine in the Lewis rat and from six colonic carcinomas induced by 1,2 dimethylhydrazine in BDIX or Fisher rats. The tumours were serially transplanted by the subcutaneous route into homologous syngeneic rats. The seven tumours differ from one another in their histological structure, five of them being well or moderately differentiated adenocarcinomas, and in their capacity to produce neutral or acidic mucins. The seven tumours also differ in their growth rate. The seven lines produced metastases; the metastatic potential and the location of the metastases differed from one line to another. The seven lines kept their original differentiation characteristics through multiple passages, representing several years of transplantation into syngeneic hosts. These tumours represent a useful and diversified model of metastatic intestinal carcinoma, available for basic research and therapeutic trials.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01606056
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