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  • 1995-1999
  • 1990-1994  (2)
  • 1991  (2)
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Years
  • 1995-1999
  • 1990-1994  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    Theophylline and ethylenediamine pharmacokinetics following administration of aminophylline to septic patients with multiorgan failure (1991)
    Springer
    Intensive care medicine 17 (1991), S. 465-468 
    Details
    ISSN: 1432-1238
    Keywords: Theophylline ; Ethylenediamine ; Pharmacokinetics ; Sepsis ; Multiorgan failure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The pharmacokinetics of theophylline and ethylenediamine were examined in 6 patients with septicaemia and multiorgan failure (MOF). The patients received a bolus injection of 4mg/kg aminophylline. Aminophylline is the ethylenediamine salt of theophylline. The clearance of theophylline was reduced in all our patients ranging from 10–66% of the value obtained in healthy volunteers. The median t1/2β was 18.8h (range 5.8–25.5) compared to a normal value of 6h. The median clearance of ethylenediamine was 54% of the normal value, while the peripheral volume of distribution was increased to 650%. Due to this t1/2β was 2.3 (2.0–2.7)h, which is 5 times the normal value of 0.55h. There was no correlation between clearance of theophylline and ethylenediamine. As theophylline has a narrow therapeutic range, routine monitoring with measurements of serum theophylline is mandatory in patients with MOF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01690768
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Digitalis enhances exercise-induced hyperkalaemia (1991)
    Springer
    European journal of clinical pharmacology 41 (1991), S. 609-611 
    Details
    ISSN: 1432-1041
    Keywords: Digitalis ; Exercise ; hyperkalaemia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In 9 patients with atrial fibrillation the effect of zero, low and high levels of serum digoxin on exercise-induced hyperkalemia was assessed by bicycle exercise tests. Exercise at each level of serum digoxin was associated with a significant (up to 20%) rise in plasma potassium. At a work load of 75 W the highest level of serum digoxin was associated with a significantly higher maximum plasma potassium concentration as compared to the maximum valueatazero serum digoxin. The enhancement of exercise-induced hyperkalemia may add to the arrhythmogenic effect of digitalis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314994
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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