ISSN:
1573-6830
Keywords:
chicken
;
pineal
;
melatoninergic cells
;
hydroxyindole-O-methyltransferase
;
constant light
;
constant darkness
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary 1. Chickens kept in constant light, as opposed to constant darkness, display a twofold increase in the activity of pineal hydroxyindole-O-methyltransferase (HIOMT), the last acting enzyme in the melatonin pathway. 2. Using an immunological approach, we presently show that this regulation of HIOMT activity reflects changes in the concentration of a single molecular form of the enzyme protein (a 38 kDa polypeptide). Immunohistofluorescence indicates that these concentration changes concurrently affect modified photoreceptors and pinealocyte-like cells in the chicken pineal organ. 3. Together, the present data support the hypothesis that environmental lighting might regulate the expression of the HIOMT gene.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00713371
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