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The relationship between the concentration of temazepam in cerebrospinal fluid and sedation in man (1992)

OSBORNE, G. A. ; BADCOCK, N. R. ; McGRATH, P. M. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Anaesthesia 47 (1992), S. 0

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ISSN: 1365-2044

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Twenty-six patients received oral temazepam and subsequently spinal anaesthesia. Blood and lumbar cerebrospinal fluid temazepam levels were measured together with the degree of sedation. The plasma and cerebrospinal fluid concentrations correlated well with the temazepam dose but even better with the weight standardised dose (r = 0.65, p = 0.0003 and r = 0.75, p = p = 0.00001 respectively). Both the plasma and cerebrospinal fluid concentrations of temazepam were correlated with the patient's sedation (r = 0.42 p = 0.037, and r = 0.46 p = 0.021 respectively), but neither was strong. Thus, although the drug concentration at the receptor may be a major factor in producing sedation, others factors, possibly the receptor population or their responsiveness, are also important contributors.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2044.1992.tb02169.x

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Is the Problem of Evil Misconceived? (1992)

McGrath, P. J.

Cambridge : Cambridge University Press

Religious studies 28 (1992), S. 61-64

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ISSN: 0034-4125

Source: Cambridge Journals Digital Archives

Topics: Theology and Religious Studies

Notes: Theism, according to David O'Connor, has in recent centuries been on trial for its life, the charge being that the existence of so much evil in the world is incompatible with belief in a benevolent creator. But this trial, he claims is incapable of producing a reasoned verdict.