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  • 1990-1994  (6)
  • 1975-1979
  • 1940-1944
  • 1993  (6)
  • 1
    Electronic Resource
    Electronic Resource
    Intrathecal Synthesis of Anti-Borrelia burgdorferi Antibodies in Neuroborreliosis: a Study with Special Emphasis on Oligoclonal IgM Antibody Bands (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 37 (1993), S. 0 
    Details
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Pre- and post-treatment (up to 3–26 months after antibiotic therapy) humoral immune responses were investigated in five neuroborreliosis patients. Anti-Borrelia (B.) burgdorferi IgG and IgM antibodies in CSF and serum were quantitated by capture ELISA. Agarose gel isoelectric focusing (AIF) and protein blotting were used to detect oligoclonal IgG and IgM bands as well as oligoclonal anti-B. burgdorferi IgG and IgM antibodies. These latter components were visualized by transfer to antigen-coated membranes (immunoblot) and immunoenzymatic staining. By ELISA, intrathecal anti-B. burgdorferi IgG and IgM antibody synthesis was detected in all initial specimens and continued 3–26 months after antibiotic therapy in four and three cases, respectively. AIF with protein blotting showed oligoclonal bands of total IgG as well as total IgM in the initial CSF specimens of all patients and persistence of such components occurred in four and five cases, respectively. By AIF and immunoblot, oligoclonal anti-B. burgdorferi IgG and IgM antibody bands could be detected in the CSF of every patient. IgG antibody bands were present in all initial CSF samples. The first specimen of one patient was negative for IgM antibody bands but such components appeared 3 weeks later. Oligoclonal CSF anti-B. burgdorferi IgG antibody components persisted over the entire follow-up periods in all but one case where they disappeared 6 weeks after treatment. The oligoclonal IgM antibodies in CSF vanished in two cases (after being present up to 4 and 11 months after antibiotic therapy) while they persisted over the entire (3–6 months after antibiotic therapy) follow-up periods in three cases. The specificity of the IgM antibody immunoblot technique was corroborated by control experiments, including antibody absorption studies and use of 41 kDa flagellar antigen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-3083.1993.tb02566.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pulmonary function in adolescents with childhood asthma (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Allergy 48 (1993), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The aim of this study was to determine the pulmonary function in former and present asthmatics. We examined 77 persons aged 12–24 years, classified into four groups: 1) healthy subjects (controls) (n= 19), 2) former asthmatics (n= 19), 3) present mild asthmatics (n= 20), and 4) present severe asthmatics (n= 19). Although exhibiting no respiratory symptoms, former asthmatics had reduced airflow values measured by FEV, (median (range) 89.7 (83–99) vs 101.4 (91–110)) and MEF25 (76.5 (68–94) vs 103.0 (97–124)), as compared with controls. Furthermore, former asthmatics had significantly increased PEF variability, as compared with controls, whereas no significant differences were found in static lung parameters, i.e. total lung capacity and residual volume, as compared with controls. In conclusion, former asthmatics, although now exhibiting no respiratory symptoms, were found to have obstructive airflow limitation, increased bronchial responsiveness, and normal lung volumes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.1993.tb00727.x
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acute renal effects of angiotensin converting enzyme inhibition in microalbuminuric type 1 diabetic patients (1993)
    Springer
    Acta diabetologica 30 (1993), S. 149-153 
    Details
    ISSN: 1432-5233
    Keywords: Angiotensin converting enzyme inhibition ; Microalbuminuria ; Renal haemodynamics ; Type 1 diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The renal effects of intravenous injection of 40 mg enalapril were investigated in 16 normotensive microalbuminuric type 1 (insulin-dependent) diabetic patients. After enalapril the following changes were observed: fractional albumin clearance (Θ Alb) decreased from 9.9 (3.0–23.8) to 8.2 (2.0–18.3)×10−6 (2P〈0.01); filtration fraction (FF) decreased from 0.260 (0.225–0.312) to 0.253 (0.190–0.297) (2P〈0.01); renal plasma flow (RPF) increased from 565 (411–690) to 623 (449–785) (2P〈0.01); and glomerular filtration rate (GFR) remained stable at 149 (128–181) versus 150 (124–185) ml · min−1 (NS). These values were unchanged after placebo (n=8), except for RFP which decreased from 606 (401–701) to 559 (381–677) ml · min−1 (2P〈0.05) and GFR which was reduced from 148 (111–173) to 138 (111–167) (2P〈0.05). A reduction in mean blood pressure from 94 (87–103) to 89 (79–101) mmHg (2P〈0.05) was found in the enalapril group and a minor reduction in the placebo group from 97 (83–106) to 96 (81–104) mmHg (2P〈0.05) was also noted. The relative changes in systolic blood pressure in the enalapril group correlated with changes in Θ Alb (Spearman'sr=0.66, 2P〈0.02) and FF (r=0.53, 2P〈0.05). Acute inhibition of angiotensin converting enzyme does not reduce the pathological hyperfiltration in these patients and a reduction in Θ Alb and FF can not be dissociated from the reduction in blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00572859
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Trapezius muscle load as a risk indicator for occupational shoulder-neck complaints (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 415-423 
    Details
    ISSN: 1432-1246
    Keywords: Shoulder-neck complaints ; Electromyographic recordings ; Static work loads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Upper trapezius muscle activity was quantified by electromyogräphic (EMG) recordings using surface electrodes to study occupational muscle load as a risk indicator for the development of shoulder-neck complaints. Thirty-nine female' production workers and thirty-two female office workers showed much larger interindividual differences than the mean difference in muscle activity between the two groups. By comparison with the production workers, the muscle activity patterns of the office workers were characterized by more short pauses and a lower static load. The median load level was similar for the two groups. For the office workers, but not for the production workers, weak correlations were found between symptoms of pain in the shoulder-neck region and some of the EMG parameters (static level and frequency of micropauses 〉 0.6 s. Current techniques for measuring shoulder muscle load by EMG recordings seem inadequate as screening methods to predict future risk of development of muscle pain symptoms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517947
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Individual and work-related risk factors associated with symptoms of musculoskeletal complaints (1993)
    Springer
    International archives of occupational and environmental health 64 (1993), S. 405-413 
    Details
    ISSN: 1432-1246
    Keywords: Musculoskeletal complaints ; Risk factors ; Repetitive work tasks ; Static loads
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Individual and work-related risk factors in the development of occupational musculoskeletal complaints were investigated in a cross-sectional study of 52 female production workers and 34 female office workers. The work tasks of the production workers were considered to generate shoulder muscle loads of low amplitude and high repetitiveness, and the work tasks of the office workers, muscle loads of low amplitude and low repetitiveness. The symptom scores were similar in the two groups, with the highest score for both groups in the shoulder-neck region. Previous pain symptoms were an important risk factor for musculoskeletal pain in all body regions, whereas psychosocial problems at work were a risk factor for complaints in the shoulder-neck region. For the office workers, 27% of the variance in shoulder-neck symptoms was explained by the variance in the parameters “previous pain symptoms” and “psychosocial problems” in a multilinear regression model. In three groups of workers with different physical loads on the shoulder muscles the symptom scores for workers without previous pain symptoms and psychosocial problems were related to the physical load. For workers with previous pain symptoms and psychosocial problems, the symptom scores were high and similar for all three groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00517946
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Picosecond resonant two-photon ionization of cold sodium clusters (1993)
    Springer
    The European physical journal 26 (1993), S. 187-188 
    Details
    ISSN: 1434-6079
    Keywords: 36.40.+d
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Large sodium clusters, up ton=21, generated by a low-temperature modification of the laser ablation gas jet source were ionized with two photons of visible radiation from an amplified picosecond dye-laser system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01429139
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    Paper (German National Licenses)
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