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  • 1990-1994  (4)
  • 1935-1939
  • 1993  (4)
  • Analytical Chemistry and Spectroscopy  (3)
  • Drug discrimination  (1)
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Material
Years
  • 1990-1994  (4)
  • 1935-1939
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The discriminative stimulus properties of legal, over-the-counter stimulants administered singly and in binary and ternary combinations (1993)
    Springer
    Psychopharmacology 110 (1993), S. 309-319 
    Details
    ISSN: 1432-2072
    Keywords: OTC stimulants ; Cocaine ; Amphetamine ; Drug discrimination ; Drug mixtures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Ninety-six male Sprague-Dawley rats were trained in one of seven drug versus saline (SAL) discrimination (DD) tasks under a variable-ratio 5–15 schedule of food-motivated lever press responding. Three groups of rats (n=12/group) were trained to discriminate between one of the legal over-the-counter (OTC) stimulants — caffeine (CAF), ephedrine (EPHED), phenylpropanolamine (PPA), and SAL. Three other groups (n=2/group) were trained to discriminate between one of three binary stimulant combinations — CAF + EPHED, CAF + PPA, EPHED + PPA, and SAL. The seventh group of rats (n=24) was trained to discriminate between SAL and a ternary combination of the OCT stimulants, CAF + EPHED + PPA. Generalization tests were conducted with each of the OTC stimulants and the controlled stimulants — amphetamine (AMPHET) and cocaine (COC). The data suggest: 1) there is cross-generalization between some OTC combinations and controlled stimulants; 2) full generalization between the OTC and controlled stimulants were demonstrated in rats trained to discriminate two of the binary stimulant combinations from SAL; 3) drug mixtures are not perceived as new entities distinct from their component elements; 4) training dose-ratio may influence the characteristics of mixture discriminations; 5) stimulus overshadowing may be a factor determining drug mixture cues, and 6) the DD properties of aggregate drug compounds may function within a euclidean metric space. We propose that some binary OTC stimulant combinations may effectively function as a methadone-like replacement therapy in cocaine dependence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02251286
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Kinetic energy effects in an ion ensemble subjected to mass-selective isolation and resonance excitation: A simulation study (1993)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 28 (1993), S. 499-509 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A simulation study is described of the behaviour of ions confined in a quadrupole ion trap during each of two separate operations of a tandem mass spectrometric experiment. The two operations are those of mass-selective ion isolation and mass-selective resonance excitation to the point of ion ejection from the ion trap. The method of mass-selective ion isolation simulated is that of consecutive ion isolation. Simulation data indicate that the collisional history of the ions prior to the isolation process can greatly influence the degree to which ions survive this process. Simulation data for mass-selective resonance ejection are compared with experimental data obtained with a Finnigan-MAT ion trap mass spectrometer. In each operation, the facility with which ions absorb energy from the field within the ion trap, whether this field is derived from the R.F. drive potential or a supplementary potential, can determine the extent to which ions are retained within the ion trap during the two mass-selective operations described.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210280506
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The influence of collisional cooling on boundary-activated decomposition in an ion-trap mass spectrometer (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 929-934 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: When the working point of a precursor ion confined within a quadrupole ion trap is moved to the vicinity of a boundary of the stability diagram, fragmentation of the precursor ion can be induced by virtue of energy gained from the radio-frequency trapping field. This behaviour is known as the ‘border effect’. When the isolated precursor ion is subjected to a cooling period of variable duration, in the presence of helium buffer gas and prior to experiencing the ‘border effect’, a high degree of control of the fragmentation pattern is achieved. The cooling period causes decreases in both ion kinetic energy and ion axial excursions. From this preliminary study, it is suggested that the deposition of internal energy during the ‘border effect’ can be varied by changing the duration of the cooling period. In addition to a degree of control of internal energy deposition, the amount of energy which can be deposited in this manner, though unknown, appears to exceed those energy levels achievable with resonance excitation and the ‘border effect’ without collisional cooling, in that an additional fragmentation channel is accessed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290071014
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Enhanced mass resolution in a quadrupole ion trap (1993)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 7 (1993), S. 43-45 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: The versatility of the quadrupole ion trap as a mass spectrometer in which the mass resolution may be varied over a wide range has been demonstrated. Mass resolution of 0.8 × 107 and 1.2 × 107 have been obtained for ions of m/z 414 and m/z 614, respectively, well in excess of the normal value of 3m, where m is the mass of ion. At the highest mass resolution, peak-widths at half-maximum are but 52 × 10-6 u. While it has been shown previously that enhanced mass reslution in the quadrupole ion trap can be achieved by reduction of the mass scanning rate, the range of mass resolutions reported here were achieved by reducing the mass scanning rate, in stages, by an overall factor of ca 5.5 × 104.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290070111
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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